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Development of Faster, Lower-Cost, High-Sensitivity Immunoassay for Specific Determination of Glucagon Using EAP-derived Monoclonal Antibodies

Award Number: R43DK106944
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2015
PERIOD OF PERFORMANCE END DATE: 01/31/2018

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Development of Faster, Lower-Cost, High-Sensitivity Immunoassay for Specific Determination of Glucagon Using EAP-derived Monoclonal Antibodies - ¿ DESCRIPTION (provided by applicant): Glucagon is a peptide hormone with a central role in the regulation of glucose metabolism, and many disorders, including Type 1 and Type 2 diabetes, are notable for abnormalities in glucagon levels. Both clinical practice and research in this field are hampered by the lack of appropriately specific and sensitive assays for glucagon levels in blood. The goal of this project is to develop and validate improved immunoassays for glucagon determination, using recently made hyperspecific monoclonal antibodies to glucagon. The new capabilities offered by these assays can lead to significant advances in the understanding of glucose homeostasis disorders and, in parallel, enable accurate clinical testing for this crucial hormone.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	SILVER LAKE RESEARCH CORPORATION	1300 WEST OPTICAL DR STE 300	AZUSA	CA	91702	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	6/15/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $220,101 )
2016	2016	SILVER LAKE RESEARCH CORPORATION	911 SOUTH PRIMROSE AVENUE	MONROVIA	CA	91016	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/29/2016	NON-COMPETING CONTINUATION	$220,101
														Subtotal = $220,101

Issue Date FY: 2015 ( Subtotal = $223,487 )
2015	2015	SILVER LAKE RESEARCH CORPORATION	911 SOUTH PRIMROSE AVENUE	MONROVIA	CA	91016	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/7/2015	NEW	$223,487
														Subtotal = $223,487

Grand Total All Awards = $443,588

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Development of Faster, Lower-Cost, High-Sensitivity Immunoassay for Specific Determination of Glucagon Using EAP-derived Monoclonal Antibodies

Award Number: R43DK106944

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2015

PERIOD OF PERFORMANCE END DATE: 01/31/2018

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