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ZEBRAFISH WOUND HEALING MODEL FOR DRUG SCREENING

Award Number: R43DK074278
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 02/15/2006
PERIOD OF PERFORMANCE END DATE: 07/31/2006

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ZEBRAFISH WOUND HEALING MODEL FOR DRUG SCREENING - DESCRIPTION (provided by applicant): Chronic wounds represent a serious health problem, exacerbated by the aging population and a significant increase in the number of diabetic patients. Slow or impaired wound healing is also a problem for immunosuppressed or bedridden individuals. Defects in the angiogenesis process are associated with slow or absence of wound healing. Although stimulating angiogenesis in chronic wounds has been shown to accelerate wound healing, drug discovery in this area has been slow. One of the major hurdles in developing effective therapeutics with this approach is that conventional in vivo assays, such as mouse and rat wound healing models, are costly and labor intensive. This SBIR aims to develop an in vivo zebrafish model to screen drugs that can improve wound healing by stimulating the process of angiogenesis. This SBIR will investigate embryogenesis, patterning, wound healing rate and angiogenic response during wound hea|ing. A zebrafish wound healing model will assist in streamlining the drug discovery process.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $166,562 )
2006	2006	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/10/2006	NEW	$166,562
														Subtotal = $166,562

Grand Total All Awards = $166,562

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ZEBRAFISH WOUND HEALING MODEL FOR DRUG SCREENING

Award Number: R43DK074278

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 02/15/2006

PERIOD OF PERFORMANCE END DATE: 07/31/2006

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