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STABILIZED PLATELETS FOR ADVANCED WOUND HEALING

Award Number: R43DK068932
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2004
PERIOD OF PERFORMANCE END DATE: 01/31/2005

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STABILIZED PLATELETS FOR ADVANCED WOUND HEALING - DESCRIPTION (provided by applicant): The overall goal of this Phase I proposal is to determine the resiliency of platelets during the stabilization process to co-accumulate secondary compounds to enhance their wound healing attributes. This work is based on the extensive documentation of pooled secretion of growth factors from platelets for healing properties and the licensing of stabilization technology for freeze-drying trehalose-loaded platelets that results in 90% recovery following rehydration with normal response to physiological agonists. By exploiting these natural properties of dry stabilized platelets with enhanced product delivery attributes and their incorporation in wound matrices and materials (hydrogels, wound bandage materials), we intend to create a dramatically improved wound healing product for the patients suffering from chronic, ulceric wounds. A range of secondary compounds, from peptides to inert polymers, and loading methodologies, from endocytotic to peptide-mediated, will be evaluated for their applicability for pre-freeze drying loading. Phase II of the project will advance the most promising loading methodologies with the leading Ioadable secondary wound healing compounds for subsequent characterization in wound bandage materials by in vitro and in vivo animal wound healing models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $99,076 )
2004	2004	ADLYFE INC	9430 KEY WEST AVENUE	ROCKVILLE	MD	20850	MONTGOMERY	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/23/2004	NEW	$99,076
														Subtotal = $99,076

Grand Total All Awards = $99,076

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STABILIZED PLATELETS FOR ADVANCED WOUND HEALING

Award Number: R43DK068932

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2004

PERIOD OF PERFORMANCE END DATE: 01/31/2005

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