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PREDICTING NEPHROPATHY IN TYPE II DIABETES

Award Number: R43DK062518
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2004
PERIOD OF PERFORMANCE END DATE: 04/30/2006

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PREDICTING NEPHROPATHY IN TYPE II DIABETES - DESCRIPTION (provided by applicant): The presence of microalbuminuria in patients with diabetes mellitus is associated with a marked increased risk of cardiovascular mortality and progression to end-stage kidney disease. Currently, there are no markers that predict which patients with diabetes will develop microalbuminuria. Based on our work examining the mechanisms of glomerular and tubular injury we have postulated that a urinary marker will precede the onset of diabetic microalbuminuria and will thus provide a very early indication of those patients who are at risk of developing diabetic nephropathy and cardiovascular events. The specific goals for the phase 1 studies are as follows: I) To establish a semi-automated assay to process a larger number of samples than is possible to do manually. II) Human studies: A) to establish normal values of the urinary marker in the general population without renal disease. B) 1. to determine the point prevalence of type 2 diabetic patients without microalbuminuria but positive urinary marker, and 2. to measure the urinary marker in type 2 diabetic patients without microalbuminuria and prospectively determining the risk of developing microalbuminuria in these patients. These phase 1 proof of concept and feasibility studies will also lay the groundwork for more definitive studies related to predictive value as well as future preventive therapies with agents targeted toward a causative mechanism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $123,021 )
2005	2005	NEPHROPATHOLOGY ASSOCIATES	10802 EXECUTIVE CENTER DRIVE	LITTLE ROCK	AR	72211	PULASKI	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	5/13/2005	NON-COMPETING CONTINUATION	$123,021
														Subtotal = $123,021

Issue Date FY: 2004 ( Subtotal = $114,789 )
2004	2004	NEPHROPATHOLOGY ASSOCIATES	10802 EXECUTIVE CENTER DRIVE	LITTLE ROCK	AR	72211	PULASKI	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	4/19/2004	NEW	$114,789
														Subtotal = $114,789

Grand Total All Awards = $237,810

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PREDICTING NEPHROPATHY IN TYPE II DIABETES

Award Number: R43DK062518

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2004

PERIOD OF PERFORMANCE END DATE: 04/30/2006

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