Tuesday, May 6, 2025
5/6/2025
Network Synchrony Neurofeedback for Opioid Dependence - Project Summary/Abstract Over the last two decades, our laboratory has characterized adaptive changes in resting state brain network synchrony in substance dependent individuals with long-term (multi-year) abstinence (LTA) from alcohol and drugs. These adaptive changes more than reverse network resting-state synchrony (RSS) differences that are associated with active substance dependence (i.e., increased appetitive drive network RSS and decreased inhibitory control and emotion- regulation network RSS). We have also shown that EEG coherence based indices reflect these same networks in the same individuals. We have recently implemented real-time 64-channel EEG coherence-based network synchrony neurofeedback (NFB) to train the brain to mimic the changes that occur with LTA. This Phase I SBIR effort will provide 12 such NFB sessions over a 8 week period to opioid dependent individuals receiving Sublocade injection Medication Assisted Treatment (MAT). Matched pairs of subjects will be studied with a cross-over design, with half of subjects receiving NFB followed by a 8 week follow-up, and their counterparts being on a 8 week waiting list followed by NFB. The non-NFB intervals allows us to estimate normal RSS changes without NFB and measure the persistence of NFB effects.
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