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Development of an Implantable On-Demand Drug Delivery Device for Behavioral Studies in Small Animals

Award Number: R43DA041173
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2015
PERIOD OF PERFORMANCE END DATE: 08/31/2017

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Development of an Implantable On-Demand Drug Delivery Device for Behavioral Studies in Small Animals - ¿ DESCRIPTION (provided by applicant): The Specific Aim of this Phase I project is to prove the feasibility of using SFC Fluidics' patented microfluidic pumping technology to develop the RatPump, a low-cost, disposable, battery-operated, implantable, on-demand, tether-free drug delivery system. The RatPump will allow real-time wirelessly controlled delivery of drugs and therapeutics to animals for addiction and behavior research models. This implantable pumping system will have substantially improved operational capacities at a much lower cost as compared to current tethered and non- tethered drug delivery systems. During the last three months of Phase I, the RatPump will be implanted and tested in rats at the McLean Psychiatric Hospital at Harvard University. The following Phase I Tasks are designed to prove feasibility of this Specific Aim. Task 1: Integration of microfluidic components into an implantable, on-demand drug delivery device. (SFC Fluidics - Months 1-4) Task 2: Demonstration of controlled fluid movement ex vivo from the drug delivery system using specified test protocol. (SFC Fluidics - Months 5-6) Task 3: Demonstration of use of implanted RatPump showing ability to deliver drugs on- demand and remotely. (Harvard/McLean Medical School - Months 7-9) Phase II will focus on modifying the Phase I RatPump prototype based on the results of Phase I testing and iterative advanced development. By the end of Phase II, SFC Fluidics will have a final design RatPump system that will deliver on-demand doses of drugs and therapeutics with an accuracy of +/- 5%. The focus of our subcontractor in Phase II will be to improve his drug addiction models as enabled by the RatPump, and to provide those data in publications, scientific conferences, and collaborations in order to facilitate the use of the RatPump toward the advancement of drug addiction models in other laboratories.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	SFC FLUIDICS, INC.	534 W RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Drug Use and Addiction Research Programs	000	1	12/1/2017	NEW	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $40,000 )
2016	2016	SFC FLUIDICS LLC	535 WEST RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Drug Use and Addiction Research Programs	000	1	3/16/2016	SUPPLEMENT FOR EXPANSION	$40,000
														Subtotal = $40,000

Issue Date FY: 2015 ( Subtotal = $175,003 )
2015	2015	SFC FLUIDICS LLC	535 WEST RESEARCH CENTER BLVD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Drug Use and Addiction Research Programs	000	1	9/15/2015	NEW	$175,003
														Subtotal = $175,003

Grand Total All Awards = $215,003

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Development of an Implantable On-Demand Drug Delivery Device for Behavioral Studies in Small Animals

Award Number: R43DA041173

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2015

PERIOD OF PERFORMANCE END DATE: 08/31/2017

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