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Production of immunogenic Ebola GP protein in maize

Award Number: R43CK000493
ORGANIZATION: NATIONAL CENTER FOR ZOONOTIC, VECTOR-BORNE, AND ENTERIC DISEASES
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2016
PERIOD OF PERFORMANCE END DATE: 02/28/2018

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Production of immunogenic Ebola GP protein in maize - ¿ DESCRIPTION (provided by applicant): The Ebola virus that causes hemorrhagic fever is a major threat to public health and a potential bioterrorism agent. There is an urgent need for new approaches to prevention and treatment of this disease both in the near and long term. Currently there are no licensed vaccines or therapeutic treatments for infection with these viruses. However, a large body of work has resulted in a number of promising candidate vaccines. These candidates are currently moving into human trials and are likely to be approved for widespread use in the near future. However, these candidates are expected to require a cold chain and trained medical personnel for administration. This can be a significant challenge in remote underdeveloped areas. Most of the problems in administering vaccines could be greatly reduced if a safe thermostable oral vaccine could be developed that eliminated the costs associated with administration by trained medical personnel and allowed for rapid dissemination among at-risk populations. One approach that has the potential to meet these objectives is a low-cost, plant-produced oral vaccine. In particular, a system using transgenic maize has emerged that has shown the characteristics needed to overcome previous limitations. This system has been used on other vaccine candidates and the work described here is aimed at developing it for use with an Ebola vaccine. The completion of Phase I should provide proof-of-concept that expression of immunogenic Ebola proteins in maize can elicit an immune response in mice. Successful completion of this work will eventually lead to the production of low cost orally delivered Ebola vaccines that do not require a cold chain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	Applied Biotechnology Institute, Inc.	1 Grand Ave Bldg 83-1d	San Luis Obispo	CA	93407	SAN LUIS OBISPO	USA	Public Health Response, Forecasting, and Analytic Capacities Related to Disease Outbreaks, Epidemics, and Pandemics	05	1	9/30/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	APPLIED BIOTECHNOLOGY INSTITUTE, INC.	CALPOLY TECHNOLOGY PARK BUILDING 83	SAN LUIS OBISPO	CA	93407	SAN LUIS OBISPO	USA	Public Health Response, Forecasting, and Analytic Capacities Related to Disease Outbreaks, Epidemics, and Pandemics	000	1	11/16/2017	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	APPLIED BIOTECHNOLOGY INSTITUTE, INC.	CALPOLY TECHNOLOGY PARK BUILDING 83	SAN LUIS OBISPO	CA	93407	SAN LUIS OBISPO	USA	Public Health Response, Forecasting, and Analytic Capacities Related to Disease Outbreaks, Epidemics, and Pandemics	000	1	11/16/2016	NEW	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $147,275 )
2016	2016	APPLIED BIOTECHNOLOGY INSTITUTE INC	1 GRAND AVENUE	SAN LUIS OBISPO	CA	93407	SAN LUIS OBISPO	USA	Public Health Response, Forecasting, and Analytic Capacities Related to Disease Outbreaks, Epidemics, and Pandemics	002	1	9/9/2016	NEW	$147,275
2016	2016	APPLIED BIOTECHNOLOGY INSTITUTE INC	1 GRAND AVENUE	SAN LUIS OBISPO	CA	93407	SAN LUIS OBISPO	USA	Public Health Response, Forecasting, and Analytic Capacities Related to Disease Outbreaks, Epidemics, and Pandemics	000	1	8/26/2016	NEW	$147,275
2016	2016	APPLIED BIOTECHNOLOGY INSTITUTE INC	1 GRAND AVENUE	SAN LUIS OBISPO	CA	93407	SAN LUIS OBISPO	USA	Public Health Response, Forecasting, and Analytic Capacities Related to Disease Outbreaks, Epidemics, and Pandemics	001	1	9/7/2016	NEW	-$147,275
														Subtotal = $147,275

Grand Total All Awards = $147,275

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Production of immunogenic Ebola GP protein in maize

Award Number: R43CK000493

ORGANIZATION: NATIONAL CENTER FOR ZOONOTIC, VECTOR-BORNE, AND ENTERIC DISEASES

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2016

PERIOD OF PERFORMANCE END DATE: 02/28/2018

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