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Cyclic Immunofluorescent Imaging in Live Cells

Award Number: R43CA298597
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Cyclic Immunofluorescent Imaging in Live Cells - PROJECT SUMMARY/ABSTRACT Cancer is a heterogeneous and dynamic disease that evolves throughout the course of treatment. Single-cell technologies have shown that the composition of tumors and the tumor microenvironment impact treatment efficacy. As such, it is challenging to predict which patients will optimally respond to current or next generation therapies (e.g. checkpoint inhibitors, cell therapies), and almost impossible to predict when or why a treatment will fail. To capture complex cellular functions and biological processes, methods need to be as dynamic as the cells they measure. The goal of this project is to determine the feasibility of using Aperture Bio’s platform for pre-clinical applications in drug development applications in organoids, as well as process development and research applications in cell therapy manufacturing, regenerative medicine, cell developmental biology, as well as oncology. The successful completion of this project will determine if Aperture Bio’s platform is suitable for the rigor required in these applications to improve current precision medicine development and delivery approaches. conjugation and quenching technologies can stain and quench live cells in multiple cellular compartments (e.g. membrane, cytosol, and nucleus) and quantify any cellular perturbations caused by multiplexed cycling.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	APERTURE BIO, INC.	34 CAMBRIDGE TER APT 3	CAMBRIDGE	MA	02140	MIDDLESEX	USA	Cancer Treatment Research	000	1	2/3/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $404,994 )
2025	2025	APERTURE BIO, INC.	127 WESTERN AVE	ALLSTON	MA	02134	SUFFOLK	USA	Cancer Treatment Research	000	1	2/24/2025	NEW	$404,994
														Subtotal = $404,994

Grand Total All Awards = $404,994

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Cyclic Immunofluorescent Imaging in Live Cells

Award Number: R43CA298597

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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