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Exonuclease Based Microsatellite Sequencing

Award Number: R43CA268242
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/12/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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Exonuclease Based Microsatellite Sequencing - Project Summary Electronic BioSciences (EBS) will investigate and develop methodologies to sequence microsatellite regions within the human genome to enable cancer genotyping via a true single-molecule, ultra-high-accuracy approach. Microsatellites are simple/short repeats (1-10 nucleotides in length) that occur in tandem 5-50 times and are among the most variable types of DNA sequence in the genome. Mutations to these microsatellite regions, or what is referred to as microsatellite instability (MSI), includes expansion or contraction of the repeat number, single nucleotide polymorphisms (SNPs), and/or insertions or deletions (indels), which have been documented with all current types of cancer. Unfortunately, current sequencing technologies, including both next generation sequencing (NGS) and third generation sequencing (TGS), are not capable of sequencing microsatellites and MSI with any sort of clinically relevant accuracy or precision due to limitations with the methodology utilized, which has significantly hindered the understanding of these types of sequences. During this Phase I SBIR program, EBS will focus on developing a new platform and sequencing approach specifically aimed at microsatellites. The investigations performed during this program will enable new approaches to probe microsatellites, MSI and the human genome in general, directly improving basic cancer research and ultimately enabling vastly improved clinical diagnostics and/or prognostics technologies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	ELECTRONIC BIOSCIENCES, INC.	5754 PACIFIC CENTER BLVD STE 204	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	1	7/24/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $400,000 )
2022	2022	ELECTRONIC BIOSCIENCES, INC.	5754 PACIFIC CTR BLVD STE 204	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Detection and Diagnosis Research	000	1	4/12/2022	NEW	$400,000
														Subtotal = $400,000

Grand Total All Awards = $400,000

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Exonuclease Based Microsatellite Sequencing

Award Number: R43CA268242

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/12/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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