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N6-Methyl-2'-O-Methyladenosine Sequencing

Award Number: R43CA243757
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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N6-Methyl-2'-O-Methyladenosine Sequencing - Project Summary During this Phase I IMAT SBIR program, Electronic BioSciences, Inc. (EBS), specialists in nanopore platform/methodology developments and high-performance electronics integration, will demonstrate RNA adenosine methylation sequencing by directly differentiating the 3 most abundant adenosine methylations: N6- methyladenosine (m6A), N6,2’-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A). Current sequencing methods cannot differentiate these three modifications because they are structurally similar, which makes them difficult to differentiate via direct sequencing methods, and because the modification is lost during sequencing-by-synthesis methods that require PCR or amplification. Hence, limitations in current sequencing technology have prevented our ability to assess adenosine methylation as it relates to cancer physiology. By laying the foundation for the development of a sequencing technology capable of direct adenosine methylation detection/differentiation, as will be carried out during this program, we will be able to significantly improve our understanding of how these RNA modification change/progress in cancer and take advantage of this knowledge for new and improved clinical and diagnostic purposes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $255 )
2023	2020	ELECTRONIC BIOSCIENCES, INC.	5754 PACIFIC CENTER BLVD STE 204	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Biology Research	000	1	5/12/2023	NEW	$255
														Subtotal = $255

Issue Date FY: 2022 ( Subtotal = -$255 )
2022	2020	ELECTRONIC BIOSCIENCES, INC.	5754 PACIFIC CTR BLVD STE 204	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Biology Research	000	1	9/26/2022	NEW	-$255
														Subtotal = -$255

Issue Date FY: 2020 ( Subtotal = $400,000 )
2020	2020	ELECTRONIC BIOSCIENCES, INC.	5754 PACIFIC CTR BLVD STE 204	SAN DIEGO	CA	92121	SAN DIEGO	USA	Cancer Biology Research	000	1	5/11/2020	NEW	$400,000
														Subtotal = $400,000

Grand Total All Awards = $400,000

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N6-Methyl-2'-O-Methyladenosine Sequencing

Award Number: R43CA243757

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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