Thursday, July 17, 2025 7/17/2025

Combined Optical and MR Microscopy System for Thin Tissue Histopathology Analysis

Award Number: R43CA193134
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2015
PERIOD OF PERFORMANCE END DATE: 12/31/2015

Group Awards By:

View Award Description

Combined Optical and MR Microscopy System for Thin Tissue Histopathology Analysis - ¿ DESCRIPTION (provided by applicant): The long term objective of the proposed project is to develop a new approach for Magnetic Resonance Imaging and Spectroscopy (MRI/MRS) microscopy: contact scanning of thin tissue sections with a 2-dimensional array of micro-coils in precise analogy to conventional histopathology of thin sections with optical microscopy. Unlike routine MRI where the spatial encoding of the images is done with magnetic gradient fields, in the current proposal the encoding will be done by the spatial distribution of the 2D array of microcoils (the depth dimension will be eliminated by using 5 micron sections). The proposed technology has the potential to add new tool for pathology analysis of tumor biopsies. High resolution MRI/MRS of thin tissue sections may provide additional information on tumor characteristics, as learned from clinical MRS studies: better differentiation between malignant and benign lesions; additional prognostic information (e.g., tumor aggressiveness); and monitoring the effect of treatment in follow-up biopsies The specific aims of the proposed project are: 1. To develop a low-scale, 2D array of microcoils and the associated signal conditioning electronics; 2. To test the microcoil array in MRI scanner to demonstrate the feasibility of contact MRI/MRS of thin histopathology tissue section. To achieve the specific aims we plan to design and manufacture a high resolution printed circuit board (PCB) with a 2-dimensional array of microcoils that will provide the spatial encoding for microscopy MRI of the tissue section. Alignment of the PCB and the tissue section will be done with a customized XY-stage, guided by microscopy view of the "sandwiched" tissue section and PCB. MRI scanning will be done in commercial high-field scanners. The MR signals induced in the microcoils will be acquired into the scanner for image construction. The regions for MRS spectra determination will be defined over the microscopic view of the registered tissue section and PCB. MRS spectra for each region will be calculated by summing signals from all coils enclosed in a specific region. The proposed technology has the potential to be developed into a commercial MRI/MRS microscope for pathology labs. If the technique is found to be clinically useful, the market will be substantil and will include pathology labs in any hospital that conducts interventional procedures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $225,000 )
2015	2015	ROBIN MEDICAL, INC	6607 BONNIE RIDGE DRIVE	BALTIMORE	MD	21209	BALTIMORE CITY	USA	Cancer Detection and Diagnosis Research	000	1	12/30/2014	NEW	$225,000
														Subtotal = $225,000

Grand Total All Awards = $225,000

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Combined Optical and MR Microscopy System for Thin Tissue Histopathology Analysis

Award Number: R43CA193134

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2015

PERIOD OF PERFORMANCE END DATE: 12/31/2015

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer