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NOVEL SOLUBLE NANOPOLYMERS FOR ENRICHMENT OF LOW ABUNDANT PHOSPHOPROTEINS

Award Number: R43CA162767
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2012
PERIOD OF PERFORMANCE END DATE: 08/31/2014

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NOVEL SOLUBLE NANOPOLYMERS FOR ENRICHMENT OF LOW ABUNDANT PHOSPHOPROTEINS - DESCRIPTION (provided by applicant): With recent technical advances, multiple important signaling pathways that may be the causes of human malignancy have continuously been discovered and dissected. The vast majority of these signaling pathways involve reversible protein phosphorylation, and the information on the location and dynamics of phosphorylation provides important mechanisms on how the signaling networks function and interact. While translational research gradually shifts from lab models to clinical samples, with the ultimate goal of identifying cancer biomarkers, a simple and reliable phosphorylation assay method is still missing for routine detection of phosphorylation in complex and typically heterogeneous clinical samples. Through this NIH SBIR Phase I study we will develop soluble nanopolymer-based reagents, termed PolyMAC (Polymer-based Metal Ion Affinity Capture), into commercial products for the highly efficient isolation of phosphopeptides. This novel design takes advantage of not only the properties of multifunctionalized nanoparticles, but more importantly, the soluble nature of the molecule, allowing for the chelation of a limited amount of phosphopeptides in the solution phase for optimum efficiency and maximum yield. We propose to finalize optimization and scalability of the reagents as commercial products. In addition, high throughput formats for comprehensive phosphoproteomic analyses will be developed to address needs of many cancer biology and proteomics research labs/facilities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $144,150 )
2013	2013	TYMORA ANALYTICAL OPERATIONS LLC	1281 WIN HENTSCHEL BOULEVARD	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Cancer Cause and Prevention Research	000	2	8/19/2013	NON-COMPETING CONTINUATION	$144,150
														Subtotal = $144,150

Issue Date FY: 2012 ( Subtotal = $150,000 )
2012	2012	TYMORA ANALYTICAL OPERATIONS LLC	1281 WIN HENTSCHEL BOULEVARD	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Cancer Cause and Prevention Research	000	1	9/17/2012	NEW	$150,000
														Subtotal = $150,000

Grand Total All Awards = $294,150

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NOVEL SOLUBLE NANOPOLYMERS FOR ENRICHMENT OF LOW ABUNDANT PHOSPHOPROTEINS

Award Number: R43CA162767

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2012

PERIOD OF PERFORMANCE END DATE: 08/31/2014

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