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METHOD FOR IDENTIFYING CANCER STEM CELLS

Award Number: R43CA139967
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2008
PERIOD OF PERFORMANCE END DATE: 04/30/2010

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METHOD FOR IDENTIFYING CANCER STEM CELLS - DESCRIPTION (provided by applicant): Several in vitro and in vivo studies have suggested that stem cell markers are shared by cancer cells in different tumor types, including CD44 in breast cancer and CD133 in brain cancer. It has also been theorized that cancer stem cells over-express vascular endothelia growth factor (VEGF). Using an antibody to mark cancer stem cells in gliomas obtained from patient specimens, investigators found that stem cell-like cancer cells expressed VEGF at a level 20 fold higher than non-tumorigenic glioma cells. In Phase I research, we propose to develop a novel, multiparameter, flow cytometry based assay to simultaneously detect CD44 and CD24 surface marker expression and level of VEGF secretion on single, viable cancer stem cells encapsulated in an agarose Gel Microdrop (GMD) matrix. PUBLIC HEALTH RELEVANCE: In this research, we will develop a novel, multiparameter, flow cytometry based assay to simultaneously detect surface marker expression and VEGF secretion on single, viable cancer stem cells encapsulated in an agarose Gel Microdrop matrix.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2008	ONE CELL SYSTEMS, INC	100 INMAN STREET	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	001	1	1/26/2009	NEW	$192,874
2009	2008	ONE CELL SYSTEMS, INC	100 INMAN STREET	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	1	1/21/2009	NEW	-$192,874
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $192,874 )
2008	2008	PHYLONIX PHARMACEUTICALS, INC	100 INMAN STREET SUITE 300	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	1	9/24/2008	NEW	$192,874
														Subtotal = $192,874

Grand Total All Awards = $192,874

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METHOD FOR IDENTIFYING CANCER STEM CELLS

Award Number: R43CA139967

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2008

PERIOD OF PERFORMANCE END DATE: 04/30/2010

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