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NANOGOLD-ENHANCED RADIOSURGERY FOR MALIGNANT BRAIN TUMORS

Award Number: R43CA134074
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2008
PERIOD OF PERFORMANCE END DATE: 06/30/2011

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NANOGOLD-ENHANCED RADIOSURGERY FOR MALIGNANT BRAIN TUMORS - DESCRIPTION (provided by applicant): This proposal builds on the unprecedented success achieved by our earlier studies in safely ablating malignant EMT-6 carcinomas in the thighs of mice by using photoactivation radiosurgery mediated by gold nanoparticles (so-called metal-enhanced radiosurgery [MERS]). MERS will be tested for its safety and efficacy in palliating imminently lethal brain tumors [transgenic v-src malignant gliomas] in mice. As the latter is a neuropathologically documented murine model of human malignant gliomas, it is expected that the proposed study will quickly and economically test the postulate that MERS shows promise to contribute to the palliation of some recurrent human gliomas by greatly decreasing the brain tumor burden, thereby enhancing the effectiveness of adjunct drugs and immunotherapies. Tested positive in mice, positive follow-up tests in rats bearing malignant gliomas and satisfactory normal-tissue tolerance tests in fewer large animals (e.g., dogs) would then enable MERS to be brought to clinical trials. PUBLIC HEALTH RELEVANCE: Malignant brain tumors have poor prognoses and new treatments are needed. Here we present a new treatment using gold nanoparticles that enables image guidance of focused irradiation and even magnification of the dose to malignant brain tumors which, if successful, could significantly improve survival.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $2,979 )
2010	2008	NANOPROBES, INC	95 HORSEBLOCK RD	YAPHANK	NY	11980	SUFFOLK	USA	Cancer Detection and Diagnosis Research	001	1	12/15/2009	NEW	$2,979
2010	2008	NANOPROBES, INC	95 HORSEBLOCK RD	YAPHANK	NY	11980	SUFFOLK	USA	Cancer Detection and Diagnosis Research	000	1	12/8/2009	NEW	$0
2010	2008	NANOPROBES, INC	95 HORSEBLOCK RD	YAPHANK	NY	11980	SUFFOLK	USA	Cancer Detection and Diagnosis Research	002	1	7/23/2010	NEW	$0
														Subtotal = $2,979

Issue Date FY: 2008 ( Subtotal = $168,449 )
2008	2008	NANOPROBES, INC	95 HORSEBLOCK RD	YAPHANK	NY	11980	SUFFOLK	USA	Cancer Detection and Diagnosis Research	000	1	6/27/2008	NEW	$168,449
														Subtotal = $168,449

Grand Total All Awards = $171,428

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NANOGOLD-ENHANCED RADIOSURGERY FOR MALIGNANT BRAIN TUMORS

Award Number: R43CA134074

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2008

PERIOD OF PERFORMANCE END DATE: 06/30/2011

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