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RAPID FISH DETECTION OF HPV RNA IN 3-DIMENSIONAL SKIN RECONSTRUCTS

Award Number: R43CA119838
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 09/26/2006
PERIOD OF PERFORMANCE END DATE: 05/31/2007

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RAPID FISH DETECTION OF HPV RNA IN 3-DIMENSIONAL SKIN RECONSTRUCTS - DESCRIPTION (provided by applicant): Human Papillomavirus (HPV) infection is clearly established as the cause of cervical cancer. A distinct cause and effect relationship of infection to cancer does not, however, exist, since the majority of infections are self-limiting, benign, and never progress to cancer. A large body of molecular research has uncovered many of the viral mechanisms believed responsible for later development of cancer, but to date has not resolved why progression to cancer takes many years to occur, if it occurs at all. This, in part, has hindered development of assays capable of predicting which patients will progress to more severe disease. The most widely used assay for HPV is the solution-based DMA hybrid capture assay (HCA). Several recent epidemiological studies have clearly shown that HCA has a strong negative predictive value; the ability to confidently state that a HPV-negative patient will not develop cervical cancer over the next several years. HCA also does not have high positive predictive value, in part due to the inability to differentiate between normal productive infection, and cells containing integrated viral DNA, which are found in dysplasia and cervical cancer. Using a novel probe labeling method, this Small Business Innovation Research project proposes to develop a sensitive in situ hybridization assay for detecting RNAs of high-risk HPV viral types. This SBIR will validate the assay using in vitro skin reconstruct models as a surrogate model for clinical HPV infections.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $182,001 )
2006	2006	ONE CELL SYSTEMS, INC	100 INMAN STREET	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	1	9/26/2006	NEW	$182,001
														Subtotal = $182,001

Grand Total All Awards = $182,001

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RAPID FISH DETECTION OF HPV RNA IN 3-DIMENSIONAL SKIN RECONSTRUCTS

Award Number: R43CA119838

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 09/26/2006

PERIOD OF PERFORMANCE END DATE: 05/31/2007

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