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MUTASORTER-CHIP TO ENRICH ULTRA-RARE CIRCULATING DNA

Award Number: R43CA118402
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 09/27/2006
PERIOD OF PERFORMANCE END DATE: 08/31/2007

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MUTASORTER-CHIP TO ENRICH ULTRA-RARE CIRCULATING DNA - DESCRIPTION (provided by applicant): Circulating DMA in blood is a strong diagnostic and prognostic indicator, making blood a valuable solid tumor surrogate for preventive cancer diagnostics as well as a noninvasive monitoring of patients who are actively under cancer therapy. Unfortunately, current nucleic-acid-based technologies are not sensitive enough to detect the circulating DNA fragments carrying rare allele mutations (associated with cancer) in the background of a higher load of normal genomic DNA (range: 1C'3 to 10~6). MSI proposes to develop the automated microfluidic MutaSorter-Chip system for the enrichment of circulating DNA fragments with mutations associated with various cancer types. The system uniquely combines bar-coded bead technology to capture rare mutant alleles via hybridization on digitally encoded micro-particles with 1 x N microfluidic sorting to subsequently enrich the captured DNA segments, followed by PCR-based screens. The platform is amenable to scale and allows thousands of different DNA segments to be screened for specific mutations (including sequence alterations as well epigenetic alterations) with high sensitivity and specificity. Phase I will be dedicated to the fabrication and feasibility testing of the bead-based microfluidic chip system for a panel of different types of mutations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $124,680 )
2006	2006	MAXWELL SENSORS, INC	10020 PIONEER BLVD	SANTA FE SPRINGS	CA	90670	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	1	9/27/2006	NEW	$124,680
														Subtotal = $124,680

Grand Total All Awards = $124,680

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MUTASORTER-CHIP TO ENRICH ULTRA-RARE CIRCULATING DNA

Award Number: R43CA118402

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 09/27/2006

PERIOD OF PERFORMANCE END DATE: 08/31/2007

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