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Novel High Resolution Scintillator for Imaging Bone Microarchitecture in Flat Panel Cone Beam CT

Award Number: R43AR073707
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Novel High Resolution Scintillator for Imaging Bone Microarchitecture in Flat Panel Cone Beam CT - Abstract Pathological changes in bone microarchitecture are associated with a broad range of musculoskeletal (MSK) diseases, including osteoporosis (OP) and osteoarthritis (OA). OP and OA carry significant healthcare burden, with an estimated 10 million US adults suffering from OP and 27 million afflicted by OA. This motivates quantitative assessment of bone microstructure on clinical imaging systems. Quantitative metrics of bone microarchitecture remain, however, underutilized in OP and OA because of limited spatial resolution of current orthopedic imaging modalities. Application of extremity CBCT in quantitative imaging of bone microstructure is likely to have high impact in OA and OP because (a) OA occurs primarily in the extremities, and (b) in OP, morphological measurements in distal extremities were shown to be indicative of fracture risk, including of hip fractures. Again, the spatial resolution of current extremity CBCT (≥0.25 mm) is insufficient to fully resolve the ≤0.1 mm trabeculae, limiting the performance in assessment of bone quality. We intend to address this specific issue through the development of a novel sensor that promises to provide the necessary resolution without compromising detector sensitivity. Efficacy of such a detector will be demonstrated through CBCT scanning and comparing results to those obtained using the current state-of-the-art system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	RADIATION MONITORING DEVICES, INC.	44 HUNT ST #2	WATERTOWN	MA	02472	MIDDLESEX	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	2/29/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $216,807 )
2018	2018	RADIATION MONITORING DEVICES, INC.	44 HUNT ST #2	WATERTOWN	MA	02472	MIDDLESEX	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	5/25/2018	NEW	$216,807
														Subtotal = $216,807

Grand Total All Awards = $216,807

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Novel High Resolution Scintillator for Imaging Bone Microarchitecture in Flat Panel Cone Beam CT

Award Number: R43AR073707

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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