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Niclosamide Formulations for the Treatment of Influenza Infections

Award Number: R43AI167394
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/08/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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Niclosamide Formulations for the Treatment of Influenza Infections - Project Summary The principal goal of this project is to demonstrate that the FDA-approved anthelminthic drug, niclosamide, can be reformulated in a synthetic lung surfactant which can be aerosolized for the treatment of infections caused by respiratory viruses. The studies proposed in this SBIR Phase I application will be focused on testing this concept by suspending niclosamide loaded liposomes in our proprietary lung surfactant technology (Niclosurf) and testing candidate Niclosurf formulations in a mouse influenza challenge model. The effectiveness of Niclosurf as a treatment for respiratory viral infections caused by influenza will be evaluated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	MOLECULAR EXPRESS, INC	2630 HOMESTEAD PL	RANCHO DOMINGUEZ	CA	90220	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	1	3/27/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $298,479 )
2022	2022	MOLECULAR EXPRESS INC	2630 HOMESTEAD PLACE	RANCHO DOMINGUEZ	CA	90220	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	1	7/8/2022	NEW	$298,479
														Subtotal = $298,479

Grand Total All Awards = $298,479

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Niclosamide Formulations for the Treatment of Influenza Infections

Award Number: R43AI167394

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/08/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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