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VesiVax Vaccine Formulation Against Neisseria gonorrhoeae

Award Number: R43AI167312
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/18/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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VesiVax Vaccine Formulation Against Neisseria gonorrhoeae - Project Summary The principal goal of this project is to develop a VesiVax®-based vaccine against Neisseria gonorrhoeae (Ng). The studies proposed in this SBIR Phase I application will be focused on co-formulating an newly identified surface-displayed outer membrane Ng protein, MtrE, with various immunostimulatory adjuvant molecules (IAMs) in the VesiVax® liposomal platform. We will characterize the immunogenicity of these VesiVax®-MtrE-IAM formulations in mice, and select for the best candidates to be further evaluated in a novel mouse upper reproductive tract Ng infection model. These studies will elucidate the immunological profile in a vaccine that will correlate with protective immunity against Ng.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	MOLECULAR EXPRESS, INC	2630 HOMESTEAD PL	RANCHO DOMINGUEZ	CA	90220	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	2	2/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $299,779 )
2023	2023	MOLECULAR EXPRESS INC	2630 HOMESTEAD PLACE	RANCHO DOMINGUEZ	CA	90220	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	2	1/13/2023	NON-COMPETING CONTINUATION	$299,779
														Subtotal = $299,779

Issue Date FY: 2022 ( Subtotal = $299,817 )
2022	2022	MOLECULAR EXPRESS INC	2630 HOMESTEAD PLACE	RANCHO DOMINGUEZ	CA	90220	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	1	2/17/2022	NEW	$299,817
														Subtotal = $299,817

Grand Total All Awards = $599,596

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VesiVax Vaccine Formulation Against Neisseria gonorrhoeae

Award Number: R43AI167312

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/18/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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