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Point-of-care diagnostic for amplification and detection of SARS-CoV-2 RNA

Award Number: R43AI165117
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/02/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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Point-of-care diagnostic for amplification and detection of SARS-CoV-2 RNA - PROJECT SUMMARY Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019 and has rapidly spread around the world. We propose the development of a diagnostic assay that will exhibit a low limit of detection of SARS-CoV-2 via a unique viral RNA amplification process. By developing a method to enrich viral RNAs over eukaryotic or bacterial RNAs we can lower the limit of detection and potentially reduce the level of false positives and negatives observed when using RT-based diagnostics. As this method is specific for viral RNA in general, it will can be used for other human ssRNA viral pathogens, such as Zika or Dengue. The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will be the development of a new step in viral RNA detection, usable for detecting SARS-CoV-2, but also other ssRNA viruses. By using an isothermal approach to amplify viral RNA our device will eliminate the need for expensive equipment, which increases access to testing. The proposed work will validate the specificity of the enzyme toward viral RNAs, develop a system to extract and detect these RNAs, and lower the detection limit for POC or at-home diagnostics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$17 )
2024	2021	LYNNTECH INC.	2501 EARL RUDDER FWY S	COLLEGE STATION	TX	77845	BRAZOS	USA	Allergy and Infectious Diseases Research	000	1	3/27/2024	NEW	-$17
														Subtotal = -$17

Issue Date FY: 2022 ( Subtotal = $3,996 )
2022	2021	LYNNTECH INC.	2501 EARL RUDDER FREEWAY S	COLLEGE STATION	TX	77845	BRAZOS	USA	Allergy and Infectious Diseases Research	000	1	10/15/2021	NEW	$3,996
														Subtotal = $3,996

Issue Date FY: 2021 ( Subtotal = $256,575 )
2021	2021	LYNNTECH INC.	2501 EARL RUDDER FREEWAY S	COLLEGE STATION	TX	77845	BRAZOS	USA	Allergy and Infectious Diseases Research	000	1	7/2/2021	NEW	$256,575
														Subtotal = $256,575

Grand Total All Awards = $260,554

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Point-of-care diagnostic for amplification and detection of SARS-CoV-2 RNA

Award Number: R43AI165117

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/02/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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