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Development of Self-Detoxifying Filter Media for Active Decontamination

Award Number: R43AI157785
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/11/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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Development of Self-Detoxifying Filter Media for Active Decontamination - PROJECT SUMMARY Systems that utilize various filtration media are one of the first lines of defense against aerosolized pathogens. They are critical in providing a safe/clean environment for patients, medical personnel, or researchers. Without these filters, those with compromised immune systems, or those working with highly contagious pathogens, can face deadly situations. Even with these filters in place, certain pathogens have the potential to pass through or even survive within the filter. Due to the small size of many viruses, the coronavirus SARS-CoV-2 is ~100nm, no filter is 100% effective at capturing all aerosolized pathogens. Furthermore, re- aerosolization of certain captured pathogens can also take place during normal use, when the filter is assessed to determine its remaining lifespan, or when the filter needs to be replaced entirely. Herein lies Lynntech’s focus in this area. Lynntech plans to address these shortcomings in filtration media through the addition of novel solid and stable hydroperoxy ligands that will immediately, and continually, terminate captured aerosolized pathogens such as the coronavirus SARS-CoV-2 virus that causes COVID-19. Self-detoxifying filters would allow for the complete termination of any pathogen that might normally remain active on untreated filters as well as eliminate the potential for re-aerosolization of active pathogens. This would allow for not only increased protection of those relying on the filters, but also mitigate the risks of those who would normally assess or change the filters. Many of the efforts towards the modification of filtration media for active decontamination have been partially successful, however, they have all come with their own drawbacks that Lynntech will attempt overcome with its own method of filter modification. During this Phase 1 project, Lynntech will demonstrate proof-of-concept by pursuing the following specific aims: (1) functionalization of commercial fiberglass-based filter media with hydroperoxy ligands, (2) assessment of antimicrobial properties of hydroperoxy-treated filters, and (3) evaluation of the “irreversibility” and safety of bound hydroperoxy ligands. Successful completion of these specific aims should demonstrate ample feasibility of using Lynntech’s filter modification technology and allow for Lynntech to plan more comprehensive technology development and commercialization avenues. Overall, this technology provides a great opportunity to drastically improve the safety of those who are working or healing in potentially harmful environments. This technology could even be extended to further decontamination avenues such as chemical warfare agents, or toxic industrial chemicals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$98 )
2024	2021	LYNNTECH INC.	2501 EARL RUDDER FWY S	COLLEGE STATION	TX	77845	BRAZOS	USA	Allergy and Infectious Diseases Research	000	1	11/6/2023	NEW	-$98
														Subtotal = -$98

Issue Date FY: 2021 ( Subtotal = $250,768 )
2021	2021	LYNNTECH INC.	2501 EARL RUDDER FREEWAY S	COLLEGE STATION	TX	77845	BRAZOS	USA	Allergy and Infectious Diseases Research	000	1	12/11/2020	NEW	$250,768
														Subtotal = $250,768

Grand Total All Awards = $250,670

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Development of Self-Detoxifying Filter Media for Active Decontamination

Award Number: R43AI157785

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/11/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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