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Low-cost Production of a Vaccine for Lyme Disease in Maize

Award Number: R43AI152650
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/02/2021
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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Low-cost Production of a Vaccine for Lyme Disease in Maize - PROJECT SUMMARY/ABSTRACT In keeping with the NIH’s stated priority for the development of vaccines to bacterial zoonoses, our goal is to develop an effective and conveniently delivered vaccine to protect against the spirochaete, Borrelia burgdorferi, the causative agent of Lyme disease. The bacterium is vectored by infected Ixodes species ticks between humans and mammalian reservoirs. Our chosen antigen candidate is OspA, a surface protein which presents as the spirochaete transits between the arthropod vector and the mammalian host. Vaccination with this antigen allows protective antibodies to encounter the spirochaete while still inside the tick as it engorges with a blood meal, and has been shown to be effective as a transmission blocking vaccine. In order to develop adequate amounts of antigen for an effective and adequate immune response, we have established a proprietorial expression system using recombinant maize. An additional advantage of maize expression is that vaccine antigens can be directly administered through the oral route rather than purified for injection. In this proposal, our goal is to produce large amounts of OspA antigen candidate in maize, orally administer the antigen to mice in feed formulated from recombinant maize flour, and demonstrate that the antigen elicits a protective immune response against challenge.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	APPLIED BIOTECHNOLOGY INSTITUTE INC	1 GRAND AVE BLDG 83-1D	SAN LUIS OBISPO	CA	93407	SAN LUIS OBISPO	USA	Allergy and Infectious Diseases Research	000	2	8/28/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $310,667 )
2022	2022	APPLIED BIOTECHNOLOGY INSTITUTE, INC.	1 GRAND AVE BLDG 83-1D CAL POLY TECHNOLOGY PK	SAN LUIS OBISPO	CA	93407	SAN LUIS OBISPO	USA	Allergy and Infectious Diseases Research	000	2	2/23/2022	NON-COMPETING CONTINUATION	$310,667
														Subtotal = $310,667

Issue Date FY: 2021 ( Subtotal = $282,857 )
2021	2021	APPLIED BIOTECHNOLOGY INSTITUTE, INC.	1 GRAND AVE BLDG 83-1D CAL POLY TECHNOLOGY PK	SAN LUIS OBISPO	CA	93407	SAN LUIS OBISPO	USA	Allergy and Infectious Diseases Research	000	1	3/2/2021	NEW	$282,857
														Subtotal = $282,857

Grand Total All Awards = $593,524

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Low-cost Production of a Vaccine for Lyme Disease in Maize

Award Number: R43AI152650

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/02/2021

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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