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Discovery of Yellow Fever Virus-Specific Epitopes for Development of an Accurate Serodiagnostic Assay

Award Number: R43AI136197
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Discovery of Yellow Fever Virus-Specific Epitopes for Development of an Accurate Serodiagnostic Assay Abstract Antibodies to many pathogenic viruses can be detected in blood, serum and/or saliva. Among these are many arboviruses, that share endemic regions in the western hemisphere and in other parts of the world. These include the related flaviviruses yellow fever virus (YFV), dengue virus (DENV), Zika virus (ZIKV) and West Nile virus (WNV) as well as the alphavirus chikungunya virus (CHIKV). Antibodies to these viruses are often cross-reactive, making diagnostics for a particular virus challenging. The current outbreak of yellow fever in Brazil and the high mortality associated with this disease as well as the recent history of outbreaks in South America and Africa create an urgent need for YFV-specific serodiagnostics, to aid control of the spread of yellow fever. Moreover, such diagnostics would facilitate clinical and public health efforts against these and other, related arboviruses. We propose a novel strategy to develop methods for specific and sensitive detection of antibodies against YFV that do not cross react with other arboviruses. We will employ an innovative, comprehensive proteomic approach with a unique serum sample collection that will allow discovery and validation of specific biomarkers capable of distinguishing YFV from other arboviruses. This will allow us to develop a specific and sensitive test for YFV infection in Phase II of this project. A practical, sensitive and specific test for YFV infection is a high priority goal due to the recent outbreak of yellow fever in Brazil, possible future outbreaks and the likely spread of yellow fever to southern US states bordering the Gulf of Mexico and Puerto Rico where Aedes spp. mosquitos might rapidly spread the infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	IMMPORT THERAPEUTICS, INC.	1 TECHNOLOGY DR STE E309	IRVINE	CA	92618	ORANGE	USA	Allergy and Infectious Diseases Research	000	2	6/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $295,679 )
2019	2019	IMMPORT THERAPEUTICS, INC.	1 TECHNOLOGY DR STE E309	IRVINE	CA	92618	ORANGE	USA	Allergy and Infectious Diseases Research	000	2	12/19/2018	NON-COMPETING CONTINUATION	$295,679
														Subtotal = $295,679

Issue Date FY: 2018 ( Subtotal = $299,564 )
2018	2018	IMMPORT THERAPEUTICS, INC.	1 TECHNOLOGY DR STE E309	IRVINE	CA	92618	ORANGE	USA	Allergy and Infectious Diseases Research	000	1	1/16/2018	NEW	$299,564
														Subtotal = $299,564

Grand Total All Awards = $595,243

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Discovery of Yellow Fever Virus-Specific Epitopes for Development of an Accurate Serodiagnostic Assay

Award Number: R43AI136197

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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