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Specific Detection of Antibodies to Emerging and Established Arboviruses Including Zika Virus

Award Number: R43AI132078
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Zika virus (ZIKV) infection is currently an epidemic in the western hemisphere. It is a WHO-declared “Public Health Emergency of International Concern” since February 2016 due to the association of ZIKV infection with microcephaly and other neurologic abnormalities in babies infected in utero and with Guillain-Barre syndrome in infected adults. An estimated four million ZIKV infections have occurred in the Americas in 2016 and over two billion people live in areas conducive to mosquito-borne transmission of ZIKV worldwide. To date, autochthonous ZIKV infection has been reported in over 40 countries in the western hemisphere including the US protectorate, Puerto Rico, and state of Florida. There is a clear need for accurate and practical methods of detecting ZIKV infection as well as for the development of therapeutic agents and vaccines to combat the associated disease. Detection of ZIKV infection is hampered, however, by the cross-reactivity of anti-ZIKV antibodies with other arboviruses present in the same areas including DENV and CHIKV and visa-versa. Specifically, neutralization- based serodiagnostic tests (notably plaque-reduction neutralization tests, PRNT) cannot cleanly distinguish between seropositivity to different members of this set of arboviruses, perhaps because antibodies directed at neutralizing epitopes tend to be cross-reactive. In this application we propose an innovative and comprehensive method for discovering targets of non-cross-reactive antibodies to emerging and established arboviruses and propose to begin with ZIKV due to the international public health emergency created by this virus.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	IMMPORT THERAPEUTICS, INC.	1 TECHNOLOGY DR STE E309	IRVINE	CA	92618	ORANGE	USA	Allergy and Infectious Diseases Research	000	1	5/29/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $224,958 )
2017	2017	IMMPORT THERAPEUTICS, INC.	1 TECHNOLOGY DR STE E309	IRVINE	CA	92618	ORANGE	USA	Allergy and Infectious Diseases Research	000	1	2/3/2017	NEW	$224,958
														Subtotal = $224,958

Grand Total All Awards = $224,958

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Specific Detection of Antibodies to Emerging and Established Arboviruses Including Zika Virus

Award Number: R43AI132078

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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