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Treatment of Wound Infection with Novel Uncharged Silver Carbene Complexes

Award Number: R43AI098214
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2012
PERIOD OF PERFORMANCE END DATE: 03/31/2015

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Treatment of Wound Infection with Novel Uncharged Silver Carbene Complexes - DESCRIPTION (provided by applicant): Three novel uncharged silver carbene microbicides that have been shown to be effective against a wide variety of pathogens will be formulated into two different ointment formulations and tested in an infected healing model in the diabetic rat. Formulation of the silver carbenes into one of either a transparent (gel) wound ointment that will allow viewing of the wound while being treated or an occlusive petrolatum-based ointment that is anticipated to have different moisture retention and drug delivery characteristics that a water-based gel will be carried out. The major specific aims of the proposed research involve the preparation & formulation/processing of the silver carbene antimicrobial agents into an ointment form, chemical and biological characterization, determination of maximum tolerated doses, and evaluation in an infected wound model in the rat. The biological characterization involves the determination of the MIC90 for each compound and evaluation of the toxicity of each compound formulated into an ointment over a two log range starting at a concentration (in the ointment) at the MIC90. The primary objectives of the proposed therapy are: 1) resolution of infection, 2) minimization of inflammation, and 3) encouragement of wound resolution. This innovative and rational approach to a topical antimicrobial therapy is founded on the basis of several different studies that have revealed promising bio-applicable attributes of these silver carbene complexes. The end-goal of this project is to enable the next phase of development of one or more of these novel microbicidal compounds that will be targeted for the treatment of infected chronic wounds and burns while developing a greater understanding of the mechanisms by which these compounds work. PUBLIC HEALTH RELEVANCE: Diabetic foot ulcers are a common type of chronic wound affecting as many as 25% of all diabetics and in many cases diabetics develop infection as a consequence of an impaired inflammatory response. Infection can greatly complicate treatment and outcomes for diabetic foot ulcers with 65% of all patients developing osteomyelitis and amputation in 14-24% of the osteomyelitis group (American Diabetes Association, 1999). Complications associated with foot ulcers account for 20-25% of all hospitalizations costing billions of dollars annually and despite the important medical advances that have been made in the treatment of diabetic foot ulcers in the past fifty years, there remains a significant need for more effective therapies to combat infection and impaired wound healing in this patient population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2012	IASIS MOLECULAR SCIENCES LLC	3305 EAST MORAN VISTA LANE	SPOKANE	WA	99223	SPOKANE	USA	Allergy and Infectious Diseases Research	001	1	9/12/2014	NEW	$0
2014	2012	IASIS MOLECULAR SCIENCES LLC	3305 EAST MORAN VISTA LANE	SPOKANE	WA	99223	SPOKANE	USA	Allergy and Infectious Diseases Research	000	1	11/8/2013	NEW	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $1,631 )
2013	2012	IASIS MOLECULAR SCIENCES LLC	3305 EAST MORAN VISTA LANE	SPOKANE	WA	99223	SPOKANE	USA	Allergy and Infectious Diseases Research	000	1	4/26/2013	NEW	$1,631
														Subtotal = $1,631

Issue Date FY: 2012 ( Subtotal = $298,369 )
2012	2012	IASIS MOLECULAR SCIENCES LLC	3305 EAST MORAN VISTA LANE	SPOKANE	WA	99223	SPOKANE	USA	Allergy and Infectious Diseases Research	000	1	9/19/2012	NEW	$298,369
														Subtotal = $298,369

Grand Total All Awards = $300,000

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Treatment of Wound Infection with Novel Uncharged Silver Carbene Complexes

Award Number: R43AI098214

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2012

PERIOD OF PERFORMANCE END DATE: 03/31/2015

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