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Characterizing neurocognitive deficits in post-acute sequelae of COVID-19

Award Number: R43AG094486
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Characterizing neurocognitive deficits in post-acute sequelae of COVID-19 - ABSTRACT Post-acute sequelae of COVID-19 (PASC), or Long COVID, is an emerging global health crisis with an urgent need for objective assessment tools to quantify neurocognitive deficits. This proposal aims to validate and leverage a novel mobile electroencephalography (EEG) platform to provide accessible, cost-effective cognitive assessments for individuals suffering from neurological manifestations of PASC (nPASC). Our preliminary data suggests that EEG/event-related potential (ERP) biosignatures, including delayed neural responses during auditory and memory tasks, are sensitive to cognitive impairments in nPASC. However, the trajectory and specificity of these deficits remain unclear. This study will validate these preliminary findings in a larger cohort (n=52) and longitudinally monitor changes over one year to map recovery or detect early signs of persistent cognitive decline. The innovative approach integrates resting-state EEG with multiple task-based ERP protocols, enabling comprehensive profiling of neural dysfunction associated with nPASC. Leveraging Advanced Brain Monitoring's FDA-cleared mobile EEG platform and validated analysis pipelines will provide a scalable solution for widespread clinical use and remote assessments. If successful, this study will deliver a quantitative EEG/ERP biomarker profile specific to neuro-PASC, enabling objective evaluation of cognitive deficits. Longitudinal monitoring will elucidate the natural trajectory, identify potential risk factors for persistent impairment, and provide outcome measures for future therapeutic interventions. This innovative diagnostic tool will empower patients and clinicians by providing objective evidence of nPASC severity and treatment efficacy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $365,227 )
2026	2026	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	2	6/25/2026	NON-COMPETING CONTINUATION	$365,227
														Subtotal = $365,227

Issue Date FY: 2025 ( Subtotal = $325,672 )
2025	2025	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	1	9/16/2025	NEW	$325,672
														Subtotal = $325,672

Grand Total All Awards = $690,899

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Characterizing neurocognitive deficits in post-acute sequelae of COVID-19

Award Number: R43AG094486

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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