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GMP Manufacturing and IND Enabling Studies of Extended-Release PNA5: A Novel Therapeutic for Treating Cognitive Impairment in Patients at-risk for Alzheimer's Disease-Related Dementias and Vascular

Award Number: R43AG085713
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/18/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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GMP Manufacturing and IND Enabling Studies of Extended-Release PNA5: A Novel Therapeutic for Treating Cognitive Impairment in Patients at-risk for Alzheimer's Disease-Related Dementias and Vascular - Vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease related dementias (ADRD) significantly contribute to the 47 million people world-wide who suffer with dementia. This number is estimated to increase to over 130 million people by 2050. Several studies have shown that VCID and conversion to ADRD are strongly correlated with vascular disease, inflammation and decreased cerebral brain blood flow. The relationship between vascular disease, cognitive function and progression to dementia and possible AD have been recently reviewed 1 and conversion rates of VCID to dementia have been reported to be approximately 45% within 5 years of diagnosis of VCID. To date, there are no approved therapies for VCID. ProNeurogen has been working to develop PNA5, a novel Angiotensin 1-7 (Ang-1–7) derivative, to treat cognitive impairment in persons at for risk ADRD and VCID. The goal of the present SBIR Phase I project is to complete GMP formulation of our extended-release (ER) subcutaneous injection formulation of PNA5 and begin GLP repeat-dose toxicology studies for the administration of our novel peptide therapy, PNA5ER, for VCID. These novel peptide formulations are designed to act on Mas receptors (MasR) within the neurovascular unit including brain vascular endothelium, neuronal cells and microglia to decrease brain reactive oxygen (ROS) production, neuroinflammation and improved brain blood flow. We have begun to translate these preclinical findings into novel peptide therapeutics to treat cognitive impairment in patients with heart disease who are at risk for ADRD or VCID. With support from NIA, we are currently completing our formal IND enabling toxicology studies required to advance PNA5 to human clinical trials for VCID and expect to submit our IND application by Q4 2023. Our current planned treatment protocol for VCID patients is once a day, subcutaneous 100 microg/kg injection using a standard needle and syringe for 85 days. However, to increase patient compliance as well as accelerate commercialization we are currently investigating new formulations that are more patient friendly and require fewer injections. We will take advantage of Pace Labs (formerly DDE) extensive experience in the formulation of GMP poly(lactic-co-glycolic acid) (PLGA) sterile injectable in-situ gel formulations and manufacturing expertise to complete the 3 principal objectives of this project. Objective I: Develop GMP manufacturing processes for PNA5ER required for IND submission. Objective II. Conduct IND enabling repeat-dose GLP toxicology studies in rats to determine the toxicokinetic and TK profiles for subcutaneously administered PNA5ER. Objective III: Complete CMC regulatory assessments and documentation for an IND amendment. Following successful completion of these studies, in Phase II we will complete GLP long-term PD/PK studies and safety studies required for IND submission.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	PRONEUROGEN INC	1970 N WENTWORTH RD	TUCSON	AZ	85749	PIMA	USA	Aging Research	000	1	7/16/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	PRONEUROGEN INC	1970 N WENTWORTH RD	TUCSON	AZ	85749	PIMA	USA	Aging Research	000	1	2/16/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $499,545 )
2023	2023	PRONEUROGEN, INC.	1970 WENTWORTH RD	TUCSON	AZ	85749	PIMA	USA	Aging Research	000	1	9/15/2023	NEW	$499,545
														Subtotal = $499,545

Grand Total All Awards = $499,545

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GMP Manufacturing and IND Enabling Studies of Extended-Release PNA5: A Novel Therapeutic for Treating Cognitive Impairment in Patients at-risk for Alzheimer's Disease-Related Dementias and Vascular

Award Number: R43AG085713

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/18/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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