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EXODOTS for diagnostic evaluation and monitoring of Alzheimer's disease

Award Number: R43AG080878
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2022
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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EXODOTS for diagnostic evaluation and monitoring of Alzheimer's disease - PROJECT SUMMARY / ABSTRACT Alzheimer's disease (AD) is the most widespread neurodegenerative disorder. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Development of an accurate and cost-effective technology for non-invasive screening and monitoring of AD before irreversible brain damage or mental decline is critical. WellSIM proposes to develop and validate a highly sensitive immunofluorescence assay, termed EXODOTS, for detection and quantification of AD core biomarkers from circulating extracellular vesicles (EV) with high accuracy, high speed, and low cost. This blood-based assay will facilitate minimally invasive assessment of AD patients in primary care settings and continuous monitoring of disease progression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	WELLSIM BIOMEDICAL TECHNOLOGIES INC	160 E TASMAN DR	SAN JOSE	CA	95134	SANTA CLARA	USA	Aging Research	000	1	7/1/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $291,692 )
2022	2022	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Aging Research	000	1	9/21/2022	NEW	$291,692
														Subtotal = $291,692

Grand Total All Awards = $291,692

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EXODOTS for diagnostic evaluation and monitoring of Alzheimer's disease

Award Number: R43AG080878

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2022

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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