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Interactive Companion Robot for Preventing Neuro-Cognitive Decline in Alzheimer's and Other Dementias

Award Number: R43AG061994
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 03/31/2022

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Interactive Companion Robot for Preventing Neuro-Cognitive Decline in Alzheimer's and Other Dementias - ABSTRACT The prevalence of Alzheimer's disease (AD) is increasing worldwide, placing enormous burdens on healthcare providers, patients and caregivers. Many new treatments are in development and the consensus is that most interventions will need to be initiated as early in the disease progression as possible. Advanced Brain Monitoring (ABM) has developed sensitive non-invasive EEG biomarkers for early detection of Alzheimer's and evaluating treatment outcomes. The biomarkers are in use in drug trials and are being validated longitudinally in a large population of patients with Alzheimer's disease, Mild Cognitive Impairment (MCI) and healthy controls. Patients with MCI are particularly interesting as potential targets for early intervention as MCI is often a transitional state between normal aging and dementia. This proposal introduces a novel, socially assistive robot (SAR) protocol designed with the goal of slowing the progression of cognitive decline in patients with MCI. The team combines ABM's 15-year success in implementing real-time neuro-sensing and dementia biomarkers with academic and commercial expertise in robot behavioral intervention design. Dr. Maja Mataric, USC Professor, Dr. Cory Kidd, CEO and founder, Catalia Health, and Dr. Schneider, USC Professor, will work with ABM to enable the Mabu robot to interact with participants in their homes and influence healthy habits. Catalia demonstrated that the Mabu software use of artificial intelligence to encourage social interaction improves medical adherence. This project will develop a SAR-mediated intervention for elderly users and MCI patients. Mabu will interact with participants in their homes to encourage and monitor the formation of healthy habits involving physical activity, specifically walking regularly. ABM's mobile EEG sensing systems will be used to assess dementia biomarkers pre- and post-robot intervention and during initial and final human-robot interactions, providing real-time metrics including engagement, workload, stress, and other measures of interactions between human and robot. The SAR is envisioned as a complementary approach that will support and enhance any combination of therapeutic interventions for dementia. The team envisions multi-stage user-robot interactions aimed at: increasing physical activity; enhancing cognitive skills; providing motivation; increasing well-being and improving quality of life. The Phase I focus is on increasing physical activity using the robot as a coach for a small cohort (10 healthy elderly; 10 MCI patients) selected from the ongoing ABM dementia biomarker study. Physical exercise is selected based on the specific evidence that increased activity can delay or slow cognitive decline. The Mabu robot will interact with participants twice daily in their homes for 6-weeks to encourage them to be more active.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	1	8/31/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	1	6/21/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	1	4/14/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $410,550 )
2018	2018	ADVANCED BRAIN MONITORING, INC.	2237 FARADAY AVE STE 100	CARLSBAD	CA	92008	SAN DIEGO	USA	Aging Research	000	1	9/20/2018	NEW	$410,550
														Subtotal = $410,550

Grand Total All Awards = $410,550

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Interactive Companion Robot for Preventing Neuro-Cognitive Decline in Alzheimer's and Other Dementias

Award Number: R43AG061994

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 03/31/2022

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