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Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

Award Number: R43AG047722
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2014
PERIOD OF PERFORMANCE END DATE: 05/31/2017

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Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease - DESCRIPTION (provided by applicant): The primary objective of the current project is to develop and evaluate the efficacy of on-line brain plasticity-based computerized assessment tool and training program for the prevention and delay of the onset of Alzheimer's disease (AD). This novel therapeutic strategy is designed to re-connect and reinvigorate Default Network (DN) brain areas by 1) increasing feed-forward power in brain systems in ways that are designed to reactivate them, and by 2) directly exercising highest-level neurological (DN) processes. Computerized assessments will be embedded in the exercise suite to further document the status of 1) DN levels of operation in the brain, 2) the complex systems that support them, and 3) important near- and far-transfer targets for training. Also, brief self-report of lifestyle stats and change provided via weekly self-rated evaluations related to health status, physical exercise, social activities, diet, sleep, mood, and self-efficacy shall provide data useful both fo evaluating real-world outcomes and product model acceptability. In the first specific aim, we will organize a series of small focus groups composed of normally aged adults to discuss and play various computer games and cognitive training programs. Based on questionnaires from and discussions with these focus groups, we will define a set of enhancements to make the user experience and the game play sufficient to motivate the forty hours of program. We will then employ established methods of software design and development and iteratively refine the implemented design to complete the development of the enhanced program for a feasibility trial conducted locally, in collaboration with the research team at the University of Iowa. Given the ease of access of online-based assessment and training, this project should result in the development of a new, powerful tool to assess and prevent the risk of onset of AD, and to provide effective adjunctive therapy those results in far greater resilience against cognitive impairment in a substantially greater pre-AD population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	POSIT SCIENCE CORPORATION	160 PINE ST STE 200	SAN FRANCISCO	CA	94111	SAN FRANCISCO	USA	Aging Research	000	3	9/8/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $476,360 )
2015	2015	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Aging Research	000	2	6/8/2015	NON-COMPETING CONTINUATION	$476,360
2015	2015	POSIT SCIENCE CORPORATION	225 Bush St FL 7	San Francisco	CA	94104	SAN FRANCISCO	USA	Aging Research	002	3	8/25/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$476,360
2015	2015	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Aging Research	001	2	8/24/2015	NON-COMPETING CONTINUATION	-$476,360
														Subtotal = $476,360

Issue Date FY: 2014 ( Subtotal = $221,540 )
2014	2014	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Aging Research	000	1	9/17/2014	NEW	$221,540
														Subtotal = $221,540

Grand Total All Awards = $697,900

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Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease

Award Number: R43AG047722

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2014

PERIOD OF PERFORMANCE END DATE: 05/31/2017

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