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TONIC AND PHASIC ALERTNESS TRAINING FOR COGNITIVE DECLINE IN AGING

Award Number: R43AG039965
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2011
PERIOD OF PERFORMANCE END DATE: 08/31/2013

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TONIC AND PHASIC ALERTNESS TRAINING FOR COGNITIVE DECLINE IN AGING - DESCRIPTION (provided by applicant): The primary objective of this Phase I application is to develop and deploy a novel, neuroplasticity- based, computerized training program that has been shown to drive positive changes in attention, working memory and executive function in a vulnerable aging population. The training approach is based on the scientific principles of brain plasticity, implemented successfully in the past with measurable improvements in cognitive function following intensive training in the elderly (1,26,47). The current approach is fundamentally novel in that it addresses the attentional state of the individual, promoting an optimal level of alertness that can then be applied to higher- order, cognitive abilities. Our data suggests that this approach may enable greater benefits from cognitive training and further generalization to untrained, resource demanding attention, working memory and executive tasks. Given the ease of access to the training regimen and its scalability (web deliverable), this form of therapy could benefit several million individuals, 65-years of age and older whose lives are limited by progressive, age-related cognitive and physical decline. PUBLIC HEALTH RELEVANCE: This project represents the translation of an effective attention training therapy, originally conceived within the academic research sector, to the marketplace via collaboration between the original developers and Brain Plasticity, Inc. This application aims to develop and behaviorally evaluate the benefits of a novel, neuroplasticity-based, computerized and web-deliverable training program suite that has been shown to drive substantial improvements in cognition. These outcomes are widely applicable to the cognitive health and life-quality of several million elderly Americans, and have further potential to offset degenerative processes common to normal aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $345,107 )
2012	2012	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Aging Research	000	2	8/6/2012	NON-COMPETING CONTINUATION	$345,107
														Subtotal = $345,107

Issue Date FY: 2011 ( Subtotal = $340,907 )
2011	2011	BRAIN PLASTICITY INC	225 BUSH STREET	SAN FRANCISCO	CA	94104	SAN FRANCISCO	USA	Aging Research	000	1	8/29/2011	NEW	$340,907
														Subtotal = $340,907

Grand Total All Awards = $686,014

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TONIC AND PHASIC ALERTNESS TRAINING FOR COGNITIVE DECLINE IN AGING

Award Number: R43AG039965

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2011

PERIOD OF PERFORMANCE END DATE: 08/31/2013

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