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An enzyme-based assay for the detection of acetaldehyde-protein adducts

Award Number: R43AA030937
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2024

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An enzyme-based assay for the detection of acetaldehyde-protein adducts - ABSTRACT Chronic alcohol consumption is a significant issue worldwide which can lead to addiction and damage throughout the body. The first step in alcohol metabolism is its conversion into acetaldehyde, which is a highly reactive and toxic molecule. The formation of acetaldehyde adducts with protein and DNA is a primary mechanism of ethanol toxicity. Acetaldehyde adducts are a direct biomarker for alcohol abuse. We intend to develop a facile and rapid enzyme-based assay for measuring acetaldehyde-protein adducts to assess alcohol use and alcohol-related health consequences.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$19 )
2025	2023	REVEL PHARMACEUTICALS INC.	2325 3RD ST STE 214	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Alcohol Research Programs	000	1	11/7/2024	NEW	-$19
														Subtotal = -$19

Issue Date FY: 2023 ( Subtotal = $272,137 )
2023	2023	REVEL PHARMACEUTICALS INC.	2325 3RD STREET	SAN FRANCISCO	CA	94107	SAN FRANCISCO	USA	Alcohol Research Programs	000	1	7/20/2023	NEW	$272,137
														Subtotal = $272,137

Grand Total All Awards = $272,118

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An enzyme-based assay for the detection of acetaldehyde-protein adducts

Award Number: R43AA030937

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2024

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