Wednesday, August 13, 2025 8/13/2025

Pharmacological Validation of GIV/Girdin, a Guanine Nucleotide Exchange Factor, for Liver Fibrosis

Award Number: R43AA025498
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2018

Group Awards By:

View Award Description

Pharmacological Validation of GIV/Girdin, a Guanine Nucleotide Exchange Factor, for Liver Fibrosis - Project Summary The broad goal of this project is the pharmacological validation of GIV, a nonreceptor guanine nucleotide exchange factor (GEF), for liver fibrosis. GIV sits at the hub of profibrogenic signaling in liver fibrosis, and is required for the key physiological events that lead to this condition: the migration, proliferation and extracellular matrix deposition of hepatic stellate cells (HSC). GIV is an ideal drug target as it is strongly ov erexpressed in the disease state, and functions independently of the extracellular signaling receptors used to instigate fibrosis. The aims of the proposal are to develop a biochemical primary screening assay, and a multiparametric phenotypic secondary assay in HSCs. The primary assay is based on the steady state GDP levels associated with GEF and its cognate G protein Gai3. The GEF activity assay will be used to screen an orthogonally pooled compound library. Hits will be confirmed and shown to be GEF specific. Following hit expansion, functional activity will be verified using the phenotypic assays. In phase II, these compounds will be profiled for selectivity and tested in animal models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	BELLBROOK LABS, LLC	5500 NOBEL DR STE 230	MADISON	WI	53711	DANE	USA	Alcohol Research Programs	000	1	12/21/2018	NEW	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $353,332 )
2016	2016	BELLBROOK LABS LLC	5500 NOBEL DRIVE SUITE 250	MADISON	WI	53711	DANE	USA	Alcohol Research Programs	000	1	9/19/2016	NEW	$353,332
														Subtotal = $353,332

Grand Total All Awards = $353,332

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Pharmacological Validation of GIV/Girdin, a Guanine Nucleotide Exchange Factor, for Liver Fibrosis

Award Number: R43AA025498

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2018

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer