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Nonlinear Computation Tool to Chart Trajectories of Bipolar Disorder

Award Number: R42MH091997
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2011
PERIOD OF PERFORMANCE END DATE: 03/31/2018

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Nonlinear Computation Tool to Chart Trajectories of Bipolar Disorder - ¿ DESCRIPTION (provided by applicant): Bipolar disorder (BD) is a complex chronic illness characterized by recurrent, often dramatic mood changes. Self-management of BD is an important component of treatment, but is likewise complex and can be fraught with difficulties including misunderstanding of the condition and a lack of self-awareness. Combined with the nationwide shortage of mental healthcare providers and the advent of the Affordable Healthcare Act, patients are assuming an increased role in understanding and managing their chronic conditions. At the same time, the emergence of mobile health and computational tools are engaging patients in self- management by enabling timely access to information and resources. The goal of this project is to complete the development of a patient-centered software system and mobile app to assist in managing bipolar disorder. In Phase I, we developed a novel computational tool known as KIOS. Based on concepts from nonlinear systems (chaos) theory, KIOS tracks multiple interacting symptoms to determine the precise state of a BD patient. Once the patient's state is identified and the trajectory of the patient is established, KIOS produces advice specific to the patient's condition to help manage the course of the disease. To demonstrate the usability of the software, KIOS was converted to an online tool with mobile access. Twenty bipolar patients evaluated KIOS in a twelve week field trial. No technical problems with the software were observed and results showed that patients had significantly more reductions in symptom severity than increases. The development of this innovative tool to help patients self-manage BD has the potential to have a profound impact on public health and achieve significant commercial success. This Phase II study has three Specific Aims: Specific Aim 1. Refine Prototype Software Specific Aim 2. Evaluate KIOS in a Randomized, Open 16 week Effectiveness Study Specific Aim 3. Integrate Data Security and Establish Quality Standards


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	BIOMEDICAL DEVELOPMENT CORPORATION	499 E HIGH ST #401	LEXINGTON	KY	40507	FAYETTE	USA	Mental Health Research Grants	000	4	6/22/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $646,204 )
2016	2016	BIOMEDICAL DEVELOPMENT CORPORATION	PO BOX 6660	SAN ANTONIO	TX	78209	BEXAR	USA	Mental Health Research Grants	000	4	3/23/2016	NON-COMPETING CONTINUATION	$646,204
														Subtotal = $646,204

Issue Date FY: 2015 ( Subtotal = $869,569 )
2015	2015	BIOMEDICAL DEVELOPMENT CORPORATION	PO BOX 6660	SAN ANTONIO	TX	78209	BEXAR	USA	Mental Health Research Grants	001	3	5/14/2015	COMPETING CONTINUATION	$140,623
2015	2015	BIOMEDICAL DEVELOPMENT CORPORATION	PO BOX 6660	SAN ANTONIO	TX	78209	BEXAR	USA	Mental Health Research Grants	000	3	4/29/2015	COMPETING CONTINUATION	$728,946
														Subtotal = $869,569

Grand Total All Awards = $1,515,773

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Nonlinear Computation Tool to Chart Trajectories of Bipolar Disorder

Award Number: R42MH091997

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2011

PERIOD OF PERFORMANCE END DATE: 03/31/2018

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