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Prospective/Retrospective Motion Correction System for Motion Robust Pediatric MR

Award Number: R42MH086984
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/26/2009
PERIOD OF PERFORMANCE END DATE: 03/31/2015

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Prospective/Retrospective Motion Correction System for Motion Robust Pediatric MR - DESCRIPTION (provided by applicant): The long term objective of the project is to develop a new motion robust magnetic resonance imaging (MRI) technology. Magnetic resonance imaging is a powerful tool that aids in the diagnosis of individual subjects, guides their clinical care, ad provides insights into the mechanisms of normal and atypical development. The characterization of mental health disorders across the lifespan has been facilitated by brain MRI. However, conventional magnetic resonance imaging requires the subject being imaged remain perfectly still for the duration of the image encoding. Young children and non-cooperative adult patients have difficulty to hold still long enough for successful imaging. For clinical imaging such patients are frequently sedated or anesthetized, which runs the risk of adverse events, is costly, and does not ensure the subjects remain perfectly still. Research studies are typically unable to use sedation or anesthesia due to its significant risk. This hampers our ability to identify the neurobiological underpinnings of mental health disorders. The development of motion robust magnetic resonance imaging will enable dramatic improvements in our capacity to chart the trajectory of mental illness over the lifespan. This will have a significant impact on our ability to determine when, where and how to intervene, and enable improved evaluation of potential interventions. The project proposes to utilize a combination of hardware for prospective motion tracking during scan and post-acquisition processing with scattered data interpolation to enable the construction of high resolution high signal-to-noise ratio images of the brain from subjects who are unable to hold still. The specific aims of this Phase II STTR application are: (1) to modify the EndoScout tracking system to enable realtime motion tracking on any scanner, with no hardware connections to the scanner and with no software changes in the scanner; (2) to accelerate retrospective processing time to achieve rapid reconstruction of motion-free 3D image set and thus to enable clinical evaluation of the scans before the subject is taken out of the scanner; (3) to apply the method to additional sequences that are needed for clinical use of the system; (4) to conduct technical tests with a moving phantom and volunteer tests to verify the performance of the system before its being used in the clinical studies: (5) to conduct a two-phase clinical study of the system, including a "try first without sedation" study in the general pediatric population and in Tuberous Sclerosis patients. This is a joint project by Robin Medical, Inc., which will develop the motion tracking system and the accelerated processing software and will conduct technical tests of the system; and the Research Section at the Department of Radiology, Children's Hospital Boston, which will develop the imaging sequences and will conduct the volunteer and clinical studies of the project.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2014 ( Subtotal = $581,946 )
2014	2014	ROBIN MEDICAL, INC	6607 BONNIE RIDGE DRIVE	BALTIMORE	MD	21209	BALTIMORE CITY	USA	Mental Health Research Grants	000	5	3/18/2014	NON-COMPETING CONTINUATION	$581,946
														Subtotal = $581,946

Issue Date FY: 2013 ( Subtotal = $585,121 )
2013	2013	ROBIN MEDICAL, INC	6607 BONNIE RIDGE DRIVE	BALTIMORE	MD	21209	BALTIMORE CITY	USA	Mental Health Research Grants	000	4	3/25/2013	NON-COMPETING CONTINUATION	$585,121
														Subtotal = $585,121

Issue Date FY: 2012 ( Subtotal = $593,878 )
2012	2012	ROBIN MEDICAL, INC	6607 BONNIE RIDGE DRIVE	BALTIMORE	MD	21209	BALTIMORE CITY	USA	Mental Health Research Grants	000	3	3/23/2012	COMPETING CONTINUATION	$593,878
														Subtotal = $593,878

Grand Total All Awards = $1,760,945

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Prospective/Retrospective Motion Correction System for Motion Robust Pediatric MR

Award Number: R42MH086984

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/26/2009

PERIOD OF PERFORMANCE END DATE: 03/31/2015

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