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Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor

Award Number: R42HL112518
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2012
PERIOD OF PERFORMANCE END DATE: 07/31/2016

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Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor - DESCRIPTION (provided by applicant): Chest pain in patients presenting to the emergency department (ED) present a clinical dilemma: transfer for emergent coronary revascularization, admit overnight for cardiac telemetry and stress testing, or discharge home with medical follow-up. In this proposal, we hypothesize that a novel thrombus-specific Spectral Computed Tomography (Multicolored CT) nanoparticle (i.e., NanoK) approach for direct rapid assessment of coronary disease in the ED could help resolve this clinical dilemma. This project, which is led by Ocean NanoTech in collaboration with Washington University, will complete development of a GLP-/GMP-ready 1- fibrin NanoK product candidate suitably advanced for GLP stability and toxicity testing to support an FDA IND. This NanoK platform technology offers unique benefits for diagnosis and treatment of acute coronary disease that could improve healthcare outcomes and reduce costs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	OCEAN NANO TECH LLC	7964 ARJONS DR STE G	SAN DIEGO	CA	92126	SAN DIEGO	USA	Cardiovascular Diseases Research	000	4	12/20/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $492,514 )
2015	2015	OCEAN NANOTECH LLC	700 RESEARCH CENTER BOULEVARD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Cardiovascular Diseases Research	000	4	7/15/2015	NON-COMPETING CONTINUATION	$492,514
														Subtotal = $492,514

Issue Date FY: 2014 ( Subtotal = $500,010 )
2014	2014	OCEAN NANOTECH LLC	700 RESEARCH CENTER BOULEVARD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Cardiovascular Diseases Research	000	3	8/19/2014	EXTENSION WITH OR WITHOUT FUNDS	$500,010
														Subtotal = $500,010

Issue Date FY: 2013 ( Subtotal = $193,077 )
2013	2013	OCEAN NANOTECH LLC	700 RESEARCH CENTER BOULEVARD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Cardiovascular Diseases Research	000	2	8/2/2013	NON-COMPETING CONTINUATION	$193,077
														Subtotal = $193,077

Issue Date FY: 2012 ( Subtotal = $199,770 )
2012	2012	OCEAN NANOTECH LLC	700 RESEARCH CENTER BOULEVARD	FAYETTEVILLE	AR	72701	WASHINGTON	USA	Cardiovascular Diseases Research	000	1	6/26/2012	NEW	$199,770
														Subtotal = $199,770

Grand Total All Awards = $1,385,371

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Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor

Award Number: R42HL112518

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2012

PERIOD OF PERFORMANCE END DATE: 07/31/2016

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