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A simple ventricular assist device for short term cardiac support

Award Number: R42HL096168
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2011
PERIOD OF PERFORMANCE END DATE: 05/31/2013

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A simple ventricular assist device for short term cardiac support - DESCRIPTION (provided by applicant): Cardiogenic shock can occur after open heart surgery or in association with myocardial infarctions, and carries a high mortality. Initiation of mechanical circulatory support can restore blood flow to vital organs and potentially save lives. In this proposal, we plan to develop a device designed to provide temporary mechanical circulatory support which is superior to currently available products in terms of safety, performance, and cost. The proposed "BioVad" uses the MC3 Mpump as a platform. The BioVad will provide self regulating, versatile, nonthrombogenic and reliable support to any adult patient with cardiogenic shock. We plan to modify the existing MC3 Mpump for prolonged support in the intensive care unit by reducing its size and weight, allowing vacuum assisted drainage, and evaluating surface coatings to reduce blood clot formation. We will test the prototype devices on a simulated circuit for performance, durability, and biocompatibility. We will then apply the device in short and long term animal models, and demonstrate superiority to predicate devices. The device will be refined, and a plan for commercialization will be established. PUBLIC HEALTH RELEVANCE: We propose to develop a temporary mechanical blood pump for the treatment of sudden heart failure and shock. Our prototype "BioVad" will be superior to currently utilized devices, and we will demonstrate its desirable features using bench simulations as well as short and long term animal studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$115 )
2017	2012	MICHIGAN CRITICAL CARE CONSULTANTS, INC.	2555 BISHOP CIR W	DEXTER	MI	48130	WASHTENAW	USA	Cardiovascular Diseases Research	000	3	5/8/2017	NON-COMPETING CONTINUATION	-$115
														Subtotal = -$115

Issue Date FY: 2012 ( Subtotal = $441,866 )
2012	2012	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	000	3	6/26/2012	NON-COMPETING CONTINUATION	$441,866
														Subtotal = $441,866

Issue Date FY: 2011 ( Subtotal = $523,429 )
2011	2011	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	001	2	6/16/2011	EXTENSION WITH OR WITHOUT FUNDS	$371,469
2011	2011	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	000	2	6/13/2011	EXTENSION WITH OR WITHOUT FUNDS	$151,960
														Subtotal = $523,429

Issue Date FY: 2010 ( Subtotal = $151,960 )
2010	2010	MICHIGAN CRITICAL CARE CONSULTANTS, INC	3550 WEST LIBERTY ST, STE 3	ANN ARBOR	MI	48103	WASHTENAW	USA	Cardiovascular Diseases Research	000	1	2/19/2010	NEW	$151,960
														Subtotal = $151,960

Grand Total All Awards = $1,117,140

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A simple ventricular assist device for short term cardiac support

Award Number: R42HL096168

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2011

PERIOD OF PERFORMANCE END DATE: 05/31/2013

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