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Distance Filtering System for Retinal Implants

Award Number: R42EY025136
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2015
PERIOD OF PERFORMANCE END DATE: 08/31/2021

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Distance Filtering System for Retinal Implants - DESCRIPTION (provided by applicant): We propose to develop and evaluate the utility of a novel input camera system for retinal prosthetics that allows users to filter optical imagery based on distance from the observer. We call this "depth filtering", which can be accomplished with a depth sensing stereoscopic camera system. Retinal prostheses can restore partial vision to people blinded by outer retinal degenerative diseases such as Retinitis Pigmentosa (RP) or Macular Degeneration. The Argus II Retinal Prosthesis System is intended to provide electrical stimulation of the retina to elicit visual perception in blind individuals with (near) total visionloss due to retinitis pigmentosa. The implanted epiretinal array provides a 10 x 6 grid of electrodes. Electrical pulses at these 60 pixel sites stimulate the retina's remaining cells and result in the perception of patterns of light. The current spatial resolution is only 60 total pixels, but the camera systems that provide image information to the prosthesis user transmit full-resolution video information. Information in the imagery consists of all visible items within the field of vie ranging for example from nearby obstacles to far away mountain scenery. The lack of perceived spatial resolution makes it extremely difficult for prosthesis users to differentiate between important nearby elements within the scene and relatively unimportant distant elements of the scenery, or vice versa. An image capture and processing system is proposed that selectively removes elements in a viewed scene that are outside a user-set depth range. We hypothesize that system utility in important tasks such as people or object finding and mobility will be less burden some, and performance improved, by providing only relevant visual information to the wearer. The proposed project seeks to develop and experiment with distance-filtered optical imagery as an input modality to retinal implants. Two prototype systems will be specified, designed, built and evaluated in Argus II patients: In phase 1 of the proposed project the image processing will be performed by a computer external to the Argus II system. In phase 2, a more powerful version of the next-generation Argus II video processing unit, capable of performing the image processing, will be utilized. This will be coupled with a new dual camera eyeglass assembly, making the phase 2 prototype fully integrated and ready for commercialization in the next generation Argus II system, and possibly in other visual prosthesis systems and head-mounted electronic low vision aids.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2017	ADVANCED MEDICAL ELECTRONICS CORP	6901 E FISH LAKE RD	MAPLE GROVE	MN	55369	HENNEPIN	USA	Vision Research	000	3	2/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Vision Research	001	3	7/30/2020	NON-COMPETING CONTINUATION	$0
2020	2017	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Vision Research	000	3	12/9/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $899,580 )
2017	2017	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Vision Research	001	3	8/25/2017	NON-COMPETING CONTINUATION	$899,580
2017	2015	ADVANCED MEDICAL ELECTRONICS CORPORATION	6901 E FISH LAKE RD STE 190	MAPLE GROVE	MN	55369	HENNEPIN	USA	Vision Research	000	1	11/21/2016	NEW	$0
														Subtotal = $899,580

Issue Date FY: 2016 ( Subtotal = $990,755 )
2016	2016	ADVANCED MEDICAL ELETRONICS CORP	7124 ARROWWOOD LANE	MAPLE GROVE	MN	55369	HENNEPIN	USA	Vision Research	001	2	9/19/2016	EXTENSION WITH OR WITHOUT FUNDS	$193,811
2016	2016	ADVANCED MEDICAL ELETRONICS CORP	7124 ARROWWOOD LANE	MAPLE GROVE	MN	55369	HENNEPIN	USA	Vision Research	000	2	9/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$796,944
														Subtotal = $990,755

Issue Date FY: 2015 ( Subtotal = $296,344 )
2015	2015	ADVANCED MEDICAL ELETRONICS CORP	7124 ARROWWOOD LANE	MAPLE GROVE	MN	55369	HENNEPIN	USA	Vision Research	000	1	8/27/2015	NEW	$296,344
														Subtotal = $296,344

Grand Total All Awards = $2,186,679

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Distance Filtering System for Retinal Implants

Award Number: R42EY025136

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2015

PERIOD OF PERFORMANCE END DATE: 08/31/2021

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