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Development of breakthrough intra-operative detector and imaging system for parat

Award Number: R42CA192243
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2012
PERIOD OF PERFORMANCE END DATE: 10/31/2017

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Development of breakthrough intra-operative detector and imaging system for parat - DESCRIPTION (provided by applicant): There are 4 parathyroid glands in the neck and they are responsible for the production of parathyroid hormone which maintains calcium homeostasis throughout the body. They are difficult to identify relative to the other tissues in the neck such s lymph nodes, fat, thyroid etc. This has resulted in the incidence of accidental parathyroid removal ranging from 8% to 19% of patients undergoing total thyroidectomy. Damage to the parathyroid gland(s) can cause hypoparathyroidism and hypocalcemia resulting in serious and deleterious side effects. There are 3 different surgery procedures in the neck region where a key part of surgery protocol is for the surgeon to visually identify the parathyroid clearly to avod accidental injury and removal. These are Thyroidectomy (involving partial or complete removal of thyroid), Parathyroidectomy (involving removal of one or more parathyroid glands) and modified Neck Dissection (involving removal of lymph nodes in neck into which cancer has spread). In a recent discovery, the PI Prof. Mahadevan-Jansen's group at Vanderbilt University reported for the first time the breakthrough finding that the Parathyroid Gland has a unique autofluorescence signature in the NIR under illumination at 785nm. The Phase 1 research demonstrated a prototype platform based on this technology that could do point detection and imaging. The specific aims of this proposal is to build upon that work and it seeks to a) Develop a product that can function in two modes: A point detection mode that can be used to confirm if a candidate tissue is parathyroid or not An imaging mode that can be used to look at a region to guide the surgeon to then using the point detection mode to confirm b) To investigate the use of the auto-fluorescence technology to assess lymph nodes intra-operatively for cancer metastases. c) To detect parathyroid vascularization via diffuse reflectance spectroscopy


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	ANASYS INSTRUMENTS CORP.	325 CHAPALA ST.	SANTA BARBARA	CA	93101	SANTA BARBARA	USA	Cancer Detection and Diagnosis Research	000	3	5/31/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	ANASYS INSTRUMENTS CORP.	325 CHAPALA ST.	SANTA BARBARA	CA	93101	SANTA BARBARA	USA	Cancer Detection and Diagnosis Research	000	3	11/3/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $544,697 )
2015	2015	ANASYS INSTRUMENTS CORPORATION	121 GRAY AVENUE	SANTA BARBARA	CA	93101	SANTA BARBARA	USA	Cancer Detection and Diagnosis Research	000	3	6/9/2015	NON-COMPETING CONTINUATION	$544,697
														Subtotal = $544,697

Issue Date FY: 2014 ( Subtotal = $591,600 )
2014	2014	ANASYS INSTRUMENTS CORPORATION	121 GRAY AVENUE	SANTA BARBARA	CA	93101	SANTA BARBARA	USA	Cancer Detection and Diagnosis Research	000	2	6/4/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$591,600
														Subtotal = $591,600

Grand Total All Awards = $1,136,297

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Development of breakthrough intra-operative detector and imaging system for parat

Award Number: R42CA192243

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2012

PERIOD OF PERFORMANCE END DATE: 10/31/2017

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