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Development of a low-cost hardware accelerator for 3D image registration

Award Number: R42CA137886
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/07/2008
PERIOD OF PERFORMANCE END DATE: 06/30/2017

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Development of a low-cost hardware accelerator for 3D image registration - DESCRIPTION (provided by applicant): Our overall goal is to develop a novel computing solution for automatic and accurate registration (spatial alignment) of 3-dimensional (3D) medical images of any modality and any anatomy (rigid or deformable) in 1 minute or less. Such capability currently does not exist. Existing image registration solutions have limited accuracy and/or limited applicability, preventing wide and routine clinical use. Building on significant prior academic research, we demonstrated the feasibility of creating the proposed technology in Phase I of this project. We now propose to create a fully functional turnkey prototype-a compact, relatively low-cost (manufacturing cost: ~$20,000) PC board-of hardware- accelerated image registration, with commercialization as the ultimate goal. Image registration is a fundamental need in modern medicine-a need that remains unmet. It is the necessary first step before images with complementary information can be fused or images taken at different times can be subtracted to quantify anatomic/physiologic changes. It is also essential when creating a population- based atlas from images of many subjects. Image registration has numerous other applications, including the registration of pre- and intra-operative images in a host of emerging minimally invasive image-guided interventions, especially those to treat cancer. Our 4 specific aims for Phase II are to: (1) create a fully integrated prototype of 1-min image registration; (2) develop software for convenient third-party integration and technology demonstration; (3) perform PACS (picture archival and communication system) integration and analyze enterprise-wide utilization; and (4) develop high- impact model applications. These aims will continue the progress made in Phase I and help create a clinically tested and viable multipurpose image registration computing technology. The proposed Phase II work will also put us in a strong position to secure private capital and licensing agreements and pursue commercialization. Our proposed low-cost, ultrafast, easy-to-use, and accurate computing solution promises to unlock the full potential of medical image registration in virtually all clinical disciplines, including radiology, oncology, neurology, and cardiology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	IGI TECHNOLOGIES, INC	4059 CANDLE LIGHT DR	DAYTON	MD	21036	HOWARD	USA	Cancer Cause and Prevention Research	000	6	2/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	IGI TECHNOLOGIES INC	5904 MEADOW ROSE	ELKRIDGE	MD	21075	HOWARD	USA	Cancer Cause and Prevention Research	000	6	6/29/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $295,007 )
2015	2015	IGI TECHNOLOGIES INC	5904 MEADOW ROSE	ELKRIDGE	MD	21075	HOWARD	USA	Cancer Cause and Prevention Research	000	6	12/16/2014	NON-COMPETING CONTINUATION	$295,007
														Subtotal = $295,007

Issue Date FY: 2014 ( Subtotal = $65,002 )
2014	2014	IGI TECHNOLOGIES INC	5904 MEADOW ROSE	ELKRIDGE	MD	21075	HOWARD	USA	Cancer Cause and Prevention Research	001	5	4/22/2014	NON-COMPETING CONTINUATION	$17,313
2014	2014	IGI TECHNOLOGIES INC	5904 MEADOW ROSE	ELKRIDGE	MD	21075	HOWARD	USA	Cancer Cause and Prevention Research	000	5	3/8/2014	NON-COMPETING CONTINUATION	$47,689
														Subtotal = $65,002

Issue Date FY: 2013 ( Subtotal = $937,008 )
2013	2013	IGI TECHNOLOGIES INC	5904 MEADOW ROSE	ELKRIDGE	MD	21075	HOWARD	USA	Cancer Cause and Prevention Research	000	4	12/31/2012	NON-COMPETING CONTINUATION	$748,757
2013	2013	IGI TECHNOLOGIES INC	5904 MEADOW ROSE	ELKRIDGE	MD	21075	HOWARD	USA	Cancer Detection and Diagnosis Research	001	4	9/4/2013	SUPPLEMENT FOR EXPANSION	$188,251
														Subtotal = $937,008

Issue Date FY: 2012 ( Subtotal = $736,244 )
2012	2012	IGI TECHNOLOGIES INC	5904 MEADOW ROSE	ELKRIDGE	MD	21075	HOWARD	USA	Cancer Cause and Prevention Research	000	3	1/18/2012	NON-COMPETING CONTINUATION	$736,244
														Subtotal = $736,244

Issue Date FY: 2011 ( Subtotal = $122,499 )
2011	2011	IGI TECHNOLOGIES INC	5904 MEADOW ROSE	ELKRIDGE	MD	21075	HOWARD	USA	Cancer Cause and Prevention Research	000	2	9/27/2011	COMPETING CONTINUATION	$122,499
														Subtotal = $122,499

Grand Total All Awards = $2,155,760

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Development of a low-cost hardware accelerator for 3D image registration

Award Number: R42CA137886

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/07/2008

PERIOD OF PERFORMANCE END DATE: 06/30/2017

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