Sunday, August 3, 2025 8/3/2025

DUAL HEADED CZT BREAST IMAGER

Award Number: R42CA128407
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2007
PERIOD OF PERFORMANCE END DATE: 08/31/2010

Group Awards By:

View Award Description

DUAL HEADED CZT BREAST IMAGER - DESCRIPTION (provided by applicant): The focus of this proposal is the development of a novel in-vivo imaging device (Molecular Breast Imaging system) that incorporates a clinical validation experiment and a limited pilot and a clinical feasibility evaluation for pre-clinical and clinical studies. Our primary intent is to facilitate the proof of feasibility of this novel imaging device for early detection, diagnosis, and treatment monitoring of breast cancer. The purpose of this imaging system is to define the characteristics of breast cancer at a molecular level using both established and novel radioactive markers that can enable the early detection and monitor the treatment of breast cancer. The novelty of this system is two fold: 1) development of a system that will comprise two opposing Cadmium Zinc Telluride (CZT) semi-conductor detectors in a specialized gantry, and 2) development of algorithms and corresponding clinical software packages that will permit absolute quantitation of tumor uptake of radiopharmaceuticals and permit monitoring of the kinetics of uptake and washout of radiopharmaceuticals in breast tissue. It is our primary goal in this Fast Track STTR proposal to create clinical tools, dual-headed breast imaging system (to be developed by GM) and software for quantitative analysis of the image data (Mayo) for functional breast imaging. Our secondary goal is demonstrate the ability of the camera to be utilized as a preclinical research device. Each facility will complete small patient trials to illustrate the potential application of this device and associated software in the evaluation of new radiopharmaceuticals for detection of breast cancer. During the Phase I of this Fast Track STTR we will construct a fully functional Dual Headed CZT breast imaging camera complete with Acquisition, Processing, Tumor Quantification, and simultaneous dual Isotope Capabilities. One tested prototype camera will be built during Phase-I and two additional cameras will emulate the original and their assembly will take place during Phase-II. During Phase-II of this proposal the primary goal is to evaluate the clinically usefulness of a dual-headed breast imaging system (to be developed by GM) and software for quantitative analysis of the image data (to be developed by Mayo). This will be accomplished through a multi-center pilot study. Three sites will conduct a patient study that will validate the ability of this device to detect sub-10 mm breast lesions. The secondary goals are 1) to compare the diagnostic capabilities of this device to MRI, 2) to explore the potential application of this device in dual-isotope studies, and 3) to demonstrate its ability to evaluate new promising radiopharmaceuticals. The secondary goals will be accomplished during Phase II and will be undertaken at all three clinical sites.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $863,519 )
2009	2009	GAMMA MEDICA INC	19355 BUSINESS CENTER DRIVE	NORTHRIDGE	CA	91324	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	001	3	8/28/2009	NON-COMPETING CONTINUATION	$863,519
2009	2008	GAMMA MEDICA INC	19355 BUSINESS CENTER DRIVE	NORTHRIDGE	CA	91324	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	2	11/20/2008	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $863,519

Issue Date FY: 2008 ( Subtotal = $862,390 )
2008	2008	GAMMA MEDICA INC	19355 BUSINESS CENTER DRIVE	NORTHRIDGE	CA	91324	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	2	9/19/2008	EXTENSION WITH OR WITHOUT FUNDS	$862,390
														Subtotal = $862,390

Issue Date FY: 2007 ( Subtotal = $201,998 )
2007	2007	GAMMA MEDICA INC	19355 BUSINESS CENTER DRIVE	NORTHRIDGE	CA	91324	LOS ANGELES	USA	Cancer Detection and Diagnosis Research	000	1	9/25/2007	NEW	$201,998
														Subtotal = $201,998

Grand Total All Awards = $1,927,907

Top

All Categories

About

Search

Reports

Data Submission

Award Information

DUAL HEADED CZT BREAST IMAGER

Award Number: R42CA128407

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2007

PERIOD OF PERFORMANCE END DATE: 08/31/2010

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer