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Unbiased longitudinal neuromorphometry for clinical decision support

Award Number: R42AG062026
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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Unbiased longitudinal neuromorphometry for clinical decision support - Project Summary Normal human neuroanatomy is incredibly variable, and increases with age. This impedes the ability of neuroimaging to detect effects in neurological conditions such as Alzheimer's disease (AD), Huntington's disease (HD), multiple sclerosis (MS) and schizophrenia. Most of the recently available state-of-the-art quantitative imaging tools still use cross-sectional methods to analyze repeated scans. These tools lack the sensitivity to monitor subtle progressive changes because such approaches do not account for the large intrinsic variability of normal neuroanatomy. The goal of this project is to commercialize a longitudinal, neuro-morphometric image processing pipeline for use in radiology, neurology and related clinical fields. The successful completion of this project will result in a clinically useful neuro-morphometric longitudinal analysis stream with more statistical power than is currently available commercially. This increase in power will directly translate into an enhanced ability to detect and assess progression at both the individual and group levels. It will also alleviate a major pain point in current longitudinal neuroradiology reading workflows, reducing radiology report turnaround times (RTAT).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	CORTICOMETRICS LLC	128 GRANITE ST	ROCKPORT	MA	01966	ESSEX	USA	Aging Research	000	3	1/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	CORTICOMETRICS LLC	128 GRANITE ST	ROCKPORT	MA	01966	ESSEX	USA	Aging Research	000	3	2/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $734,079 )
2021	2021	CORTICOMETRICS LLC	128 GRANITE ST	ROCKPORT	MA	01966	ESSEX	USA	Aging Research	002	3	6/4/2021	NON-COMPETING CONTINUATION	$734,079
2021	2020	CORTICOMETRICS LLC	128 GRANITE ST	ROCKPORT	MA	01966	ESSEX	USA	Aging Research	001	2	4/12/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
2021	2019	CORTICOMETRICS LLC	128 GRANITE ST	ROCKPORT	MA	01966	ESSEX	USA	Aging Research	000	1	3/12/2021	NEW	$0
														Subtotal = $734,079

Issue Date FY: 2020 ( Subtotal = $733,415 )
2020	2020	CORTICOMETRICS LLC	128 GRANITE ST	ROCKPORT	MA	01966	ESSEX	USA	Aging Research	001	2	8/11/2020	EXTENSION WITH OR WITHOUT FUNDS	$733,415
2020	2019	CORTICOMETRICS LLC	128 GRANITE ST	ROCKPORT	MA	01966	ESSEX	USA	Aging Research	000	1	8/3/2020	NEW	$0
														Subtotal = $733,415

Issue Date FY: 2019 ( Subtotal = $224,843 )
2019	2019	CORTICOMETRICS LLC	128 GRANITE ST	ROCKPORT	MA	01966	ESSEX	USA	Aging Research	000	1	6/27/2019	NEW	$224,843
														Subtotal = $224,843

Grand Total All Awards = $1,692,337

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Unbiased longitudinal neuromorphometry for clinical decision support

Award Number: R42AG062026

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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