Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

High-throughput Organoid Platform for Electrophysiology Studies (HOPES)

Award Number: R41TR006349
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/17/2026
PERIOD OF PERFORMANCE END DATE: 08/16/2027

Group Awards By:

View Award Description

High-throughput Organoid Platform for Electrophysiology Studies (HOPES) - ABSTRACT Organoids provide cutting edge representations of human organs that are an invaluable tool for studying complex disease and drug interactions with improved in vivo correlation. Despite their promise, high throughput compatible culture and assay of organoids remains challenging. As the most advanced organoid platform, brain organoids represent the human brain and provide promise for investigation of diseases such as Alzheimer’s disease and Parkinson’s disease, among others. Further, neurotoxins represent serious environmental contaminants and military threats. CFD Research has developed a microphysiological system (MPS) that utilizes cortical organoids as an agnostic, environmental hazard sensors. We propose to adapt this system into an integrated, automated platform for the growth and maturation of organoids, and for high throughput screening. Our overarching goal (at the end of Phase II) is to manufacture and demonstrate an integrated, High-throughput Organoid Platform for Electrophysiology Studies (HOPES). The HOPES platform will contain a high density, extremely low-noise multi-well 3D MEA integrated into a MPS chip for automated growth, maintenance, and interrogation of 96 organoids with vascularized flow. To enable this approach, we have partnered with Dr. Patrick Mercier at the University of California, San Diego (UCSD), an expert in microelectronics to integrate amplification and signal processing directly into the HOPES cartridge for extremely low noise, low power detection of electrophysiological activity. During the phase I effort we will develop the MEA recording system on chips, demonstrate the developed system on chip with commercial multi-well MEA plates. Further, we will develop the MPS cartridge that will interface to multiplexed, 3D MEAs (phase II) and demonstrate the formation of flow paths for co-culture of organoids and endothelial. To accomplish this challenging project, we have assembled a team with expertise in all aspects of the proposed work: microphysiological systems/organs on a chip, system automation and integration (Drs. Roehm, and German; CFD Research), microelectronics and neurological recording systems (Dr. Patrick Mercier; University of California San Diego). Upon successful completion of the Phase I effort, Phase II will focus on integrating the phase I proof of concept device and on-chip signal processing (reduced data transfer requirements) into an integrated prototype containing a multi-well 3D MEA directly connected to the recording system designed in this work through glass vias to create the integrated HOPES system. Overall, the HOPES will provide value to pharmaceutical companies seeking cures to diseases, as well as medical countermeasures for both civilian and military threats.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $349,752 )
2026	2026	CFD RESEARCH CORPORATION	6820 MOQUIN DR NW	HUNTSVILLE	AL	35806	MADISON	USA	National Center for Advancing Translational Sciences	000	1	8/17/2026	NEW	$349,752
														Subtotal = $349,752

Grand Total All Awards = $349,752

Top

All Categories

About

Search

Reports

Data Submission

Award Information

High-throughput Organoid Platform for Electrophysiology Studies (HOPES)

Award Number: R41TR006349

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/17/2026

PERIOD OF PERFORMANCE END DATE: 08/16/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer