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A Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging

Award Number: R41MH123253
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/07/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2022

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A Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging - Project Summary Medical imaging technologies such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have been widely used in studying the underlying mechanisms of mental illnesses and neurological disorders such as brain tumors, Alzheimer’s disease, epilepsy, and depression, etc. However, PET and MRI scans are almost always ordered as separate studies on separate machines, often resulting in weeks of delay in acquiring critical information about a patient’s disease. The recent rise of hybrid PET/MRI has enabled the simultaneous acquisition of anatomical, functional, and molecular information about the patient. However, its accessibility is limited by the high cost ($5M) of the commercial permanently integrated PET+MRI systems (+ an additional $1.5-2M room renovation cost). Today, only about 40 PET/MRI systems are installed in the US compared to almost 13,000 installed MRI systems. Moreover, the design and geometry of the commercial whole- body PET/CT and PET/MRI systems are not optimized for brain imaging, resulting in poorer sensitivity and spatial resolution achievable for neurological studies. To address these needs, PETcoil is proposing to develop a portable PET insert that can be installed into (and removed from) any existing MRI systems to achieve simultaneous PET/MRI for a fraction of the cost compared to installing an integrated PET+MR system. In addition to significantly lower cost, the proposed PET insert also provides 3 times higher photon sensitivity and 4 times finer volumetric spatial resolution compared to state-of-the-art whole-body integrated PET+MR systems. Key to facilitating this removable insert concept is the novel “radiofrequency (RF)-penetrable” technology we have developed at Stanford. In this Phase I project, we will create a compact and scalable design of the PET detector module ready for scaling up to a full RF-penetrable PET insert system for a Phase II proposal. We will also validate the MRI compatibility of the PET detector modules by comparing the PET and MRI performance results acquired with the PET detector modules outside the MRI system to those acquired inside 3 MRI systems under simultaneous PET and MRI operation. The success of this project will mitigate risks toward the commercialization of the first portable time-of-flight (TOF) RF-penetrable PET scanner insert that leverages existing MRI systems to achieve simultaneous TOF-PET/MR brain imaging, without requiring modifications to the MR system hardware. The proposed portable PET insert can greatly disseminate PET/MRI for brain imaging and facilitate the research and clinical characterization of a wide variety of neurological disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	PETCOIL, INC.	1257B OAKMEAD PKWY	SUNNYVALE	CA	94085	SANTA CLARA	USA	Mental Health Research Grants	000	2	8/9/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	PETCOIL, INC.	1257B OAKMEAD PKWY	SUNNYVALE	CA	94085	SANTA CLARA	USA	Mental Health Research Grants	000	2	7/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $497,108 )
2021	2021	PETCOIL, INC.	1257B OAKMEAD PKWY	SUNNYVALE	CA	94085	SANTA CLARA	USA	Mental Health Research Grants	001	2	7/1/2021	NON-COMPETING CONTINUATION	$0
2021	2021	PETCOIL, INC.	1257B OAKMEAD PKWY	SUNNYVALE	CA	94085	SANTA CLARA	USA	Mental Health Research Grants	000	2	3/20/2021	NON-COMPETING CONTINUATION	$497,108
2021	2021	PETCOIL, INC.	1257B OAKMEAD PKWY	SUNNYVALE	CA	94085	SANTA CLARA	USA	Mental Health Research Grants	002	2	9/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $497,108

Issue Date FY: 2020 ( Subtotal = $494,652 )
2020	2020	PETCOIL, INC.	505 CYPRESS POINT DR UNIT 89	MOUNTAIN VIEW	CA	94043	SANTA CLARA	USA	Mental Health Research Grants	000	1	4/7/2020	NEW	$494,652
2020	2020	PETCOIL, INC.	505 CYPRESS POINT DR UNIT 89	MOUNTAIN VIEW	CA	94043	SANTA CLARA	USA	Mental Health Research Grants	001	1	9/15/2020	NEW	$0
														Subtotal = $494,652

Grand Total All Awards = $991,760

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A Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging

Award Number: R41MH123253

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/07/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2022

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