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A hormonal therapy for preeclampsia

Award Number: R41HD082698
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/13/2015
PERIOD OF PERFORMANCE END DATE: 12/31/2015

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A hormonal therapy for preeclampsia - DESCRIPTION (provided by applicant): Preeclampsia is a pregnancy-specific, hypertensive disorder that can lead to multi-organ failure, seizure, and maternal death. Preeclampsia is also responsible for as many as 20% of premature births in the United States. Although better neonatal care has improved the likelihood of preterm babies surviving, many face increased mortality and serious long-term morbidities. It is generally agreed that the best approach to prevent adverse preeclampsia-associated complications is to delay premature birth. Unfortunately, current treatments are ineffective at delaying labor by more than a couple of days in the majority of preeclampsia patients. Although the cause of preeclampsia remains to be clearly defined, preeclampsia has been proposed to involve an altered balance between pro- and anti-angiogenic factors, dysregulated immune response to the allogenic fetus, incomplete trophoblast invasion and remodeling of spiral arteries, or a combination of impaired oxygen supply and placental oxidative stress. These defects could lead to restricted maternal-fetal blood circulation and systemic endothelial dysfunction, leading to high blood pressure, proteinuria, and fetal growth restriction. Recent studies have shown that signaling of CLR/RAMP receptors plays critical roles in the development of feto-placental tissues, and vasotone regulation during pregnancy. Importantly, it has been shown that blocking of CLR/RAMP receptor signaling leads to preeclampsia-like symptoms in pregnant animals. On the other hand, the activation of CLR/RAMP receptors can dampen preeclampsia-like symptoms in animals that have been pretreated with a nitric-oxide-synthase inhibitor or a CLR/RAMP receptor antagonist. Therefore, pharmacological activation of CLR/RAMP receptors could be a promising approach for treating hypertension, proteinuria, and fetal growth restriction in preeclampsia patients. Our goal is to develop a hormonal therapy based on stable CLR/RAMP receptor agonists that we recently developed. This therapy is expected to have potent efficacy in reducing blood pressure, edema, proteinuria, and fetal growth restriction in preeclampsia patients, thereby reducing preterm birth resulting from preeclampsia. Successful demonstration of the efficacy of lead compounds would validate our drug candidates, and facilitate the preclinical development of these therapeutic candidates in the Phase II STTR investigation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2015 ( Subtotal = $223,676 )
2015	2015	ADEPTHERA LLC	3353 ALMA STREET	PALO ALTO	CA	94306	SANTA CLARA	USA	Child Health and Human Development Extramural Research	000	1	1/13/2015	NEW	$223,676
														Subtotal = $223,676

Grand Total All Awards = $223,676

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A hormonal therapy for preeclampsia

Award Number: R41HD082698

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/13/2015

PERIOD OF PERFORMANCE END DATE: 12/31/2015

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