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Develop technology platform to transform the diagnosing, monitoring and treating of opioid use disorders

Award Number: R41DA044905
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2017
PERIOD OF PERFORMANCE END DATE: 10/30/2018

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Develop technology platform to transform the diagnosing, monitoring and treating of opioid use disorders - PROJECT ABSTRACT There are two big challenges to reducing the number of substance use disorders (SUDs) in the United States: 1) Almost 90% of the 21.7 million people who suffer from SUDs are never professionally diagnosed and never seek treatment [1] and 2) treatment for the small minority that does seek help is not very effective with relapse rates estimated to be between 65% and 90% within the first year after treatment, depending on the substance that is being misused [2]. The Clinical Addiction Recovery Institute (C.A.R.I.), a Mentor on the Go LLC company, aims to address both of those challenges by developing a continuous monitoring system based on an injectable, subcutaneously implanted biosensor, approximately the size of a grain of rice that can detect and monitor substance use byproducts in the interstitial fluid. The C.A.R.I system for detecting and monitoring substance misuse will integrate wearable sensor technology with an already developed mobile smartphone application that will enable physicians to more easily detect, monitor and treat substance misuse. Currently no other solutions exist that can detect multiple substances and measure them continuously over time. This Phase I project will focus on the detection of an opioid substance and will test the hypothesis that a minimally invasive injectable biosensor with a minimum lifetime of one month can successfully measure a biomarker needed to detect opioid use. Aim 1 of this project will develop a low-power electrochemical injectable biosensor that can communicate wirelessly with a wearable device and smartphone while Aim 2 will involve the selection and development of an electrochemical opioid assay for use in the biosensor. The results from these studies will provide not only the proof of concept that opioid use can be detected in interstitial fluid, but also the basis for the implantable biosensor component of the proposed C.A.R.I. system, which will be a vast improvement over the intermittent monitoring data that is currently available via self-reporting, urine screening, and blood testing. When fully developed, the proposed C.A.R.I. system will enable clinicians to be more precise with dosing and safety planning for opioid use treatment, thereby lowering relapse rates and improving treatment outcomes for patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	MENTOR ON THE GO, LLC	4810 YEARLING GLEN RD	SAN DIEGO	CA	92130	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	1	5/23/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $235,848 )
2017	2017	MENTOR ON THE GO, LLC	4810 YEARLING GLEN RD	SAN DIEGO	CA	92130	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	1	7/17/2017	NEW	$235,848
														Subtotal = $235,848

Grand Total All Awards = $235,848

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Develop technology platform to transform the diagnosing, monitoring and treating of opioid use disorders

Award Number: R41DA044905

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2017

PERIOD OF PERFORMANCE END DATE: 10/30/2018

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