Wednesday, September 3, 2025 9/3/2025

Validating novel DNA repair deficient cancer therapy targets and small molecule compounds

Award Number: R41CA275627
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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Validating novel DNA repair deficient cancer therapy targets and small molecule compounds - Abstract Single-strand DNA repair (ssDR) is critical for preventing genomic catastrophe. AnaNeo Therapeutics was founded by experts in DNA repair mechanisms. Extending our team’s previous fundamental ssDR studies we analyzed >61,000 tumors for somatic mutations, generated isogenic mutant/wild-type cell line pairs, screened two isogenic cell line pairs with small molecule libraries, performed computational and experimental synthetic lethality (SL) screens and used state-of-the-art Schrodinger Maestro drug docking software to nominate small molecule ssDR SL hits. Here in this Phase I STTR project we propose to validate candidate targets and small molecule inhibitors. Overall, this study will nominate innovative ssDR SL precision therapy targets and small molecule hits for lead optimization in future Phase II SBIR studies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	ANANEO THERAPEUTICS INC	885 3RD AVE	NEW YORK	NY	10022	NEW YORK	USA	Cancer Biology Research	000	1	12/18/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	ANANEO THERAPEUTICS INC.	885 3RD AVE FL 20	NEW YORK	NY	10022	NEW YORK	USA	Cancer Biology Research	000	1	10/31/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $398,917 )
2022	2022	ANANEO THERAPEUTICS INC.	885 3RD AVE FL 20	NEW YORK	NY	10022	NEW YORK	USA	Cancer Biology Research	000	1	8/8/2022	NEW	$398,917
														Subtotal = $398,917

Grand Total All Awards = $398,917

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Validating novel DNA repair deficient cancer therapy targets and small molecule compounds

Award Number: R41CA275627

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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