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Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Systemic Lupus Erythematosus

Award Number: R41AI179213
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/21/2023
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Systemic Lupus Erythematosus - PROJECT SUMMARY Lupus is a chronic, systemic autoimmune disease in which cells of the immune system attack organ systems throughout the body including the kidneys, brain, and lungs and that presents heterogeneously with symptoms that can include fever, arthritis, alopecia, stroke, and heart attack. Lupus is driven by autoreactive B and CD4 T cells with a particular role for TfH and TH17 CD4 T cells. Current therapies for lupus can be effective but only work on a subset of patients, lack biomarkers to resolve the heterogeneity of the disease as it relates to treatment efficacy, and are associated with significant and sometimes severe side effects. New safe and effective therapies are needed to treat lupus. The deoxyribonucleoside salvage pathway with rate-limiting enzyme deoxycytidine (dCK) salvages extracellular deoxyribonucleosides for intracellular deoxyribonucleotide metabolism. dCK activity can be measured non-invasively in vivo in mice and humans using the PET radiotracers [18F]FAC and [18F]CFA, respectively. dCK activity is upregulated in lymphocytes in multiple preclinical models of autoimmune diseases including autoimmune hepatitis and multiple sclerosis (MS). One study showed that dCK activity is upregulated in the lymph nodes in a mouse lupus model at the one time-point analyzed. Trethera has recently developed TRE-515 as a potent and selective small molecule dCK inhibitor with excellent in vivo pharmacokinetic and pharmacodynamic properties. TRE-515 was recently cleared by the FDA (IND# 131939) for investigational use in the treatment of solid tumors and has been safely administered to multiple patients in Phase I clinical trials. We recently showed in multiple experimental autoimmune encephalomyelitis (EAE) mouse models of MS that dCK activity is upregulated in lymphocytes during disease using [18F]FAC PET, that TRE-515 can limit dCK activity in lymphoid tissues in vivo, that TRE-515 can block clinical MS symptoms in these EAE mouse models when treatments are initiated at disease induction or at symptoms onset, that therapeutic efficacy in these models is associated with a measurable increase in plasma deoxycytidine levels, that TRE-515 limits disease in these models by blocking activation-induced T and B cell proliferation without affecting other cells in the immune system, and that TRE-515 directly blocks T cell proliferation in culture. MS and lupus are different diseases but share activated and proliferating CD4 T and B cells as a common driver of disease. We hypothesize that TRE- 515 could be an effective treatment for lupus. We will begin to test this hypothesis in this Phase I STTR grant through two aims. Aim 1: To quantify dCK activity in the lymphoid organs throughout disease using [18F]FAC PET in a preclinical lupus model. Aim 2: To test whether the dCK inhibitor TRE-515 blocks disease progression in a lupus model.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	TRETHERA CORP	13451 RAND DR	SHERMAN OAKS	CA	91423	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	2	9/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $305,715 )
2024	2024	TRETHERA CORP	13451 RAND DR	SHERMAN OAKS	CA	91423	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	2	5/14/2024	NON-COMPETING CONTINUATION	$305,715
														Subtotal = $305,715

Issue Date FY: 2023 ( Subtotal = $305,135 )
2023	2023	TRETHERA CORP	13451 RAND DR	SHERMAN OAKS	CA	91423	LOS ANGELES	USA	Allergy and Infectious Diseases Research	000	1	6/21/2023	NEW	$305,135
														Subtotal = $305,135

Grand Total All Awards = $610,850

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Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleoside Salvage Pathway to Treat Systemic Lupus Erythematosus

Award Number: R41AI179213

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/21/2023

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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