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EXODUS-enabled High-throughput Multi-omics Profiling of Extracellular Vesicles for Diagnosis of Preclinical Alzheimer's Disease

Award Number: R41AG076098
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2021
PERIOD OF PERFORMANCE END DATE: 09/29/2023

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EXODUS-enabled High-throughput Multi-omics Profiling of Extracellular Vesicles for Diagnosis of Preclinical Alzheimer's Disease - PROJECT SUMMARY / ABSTRACT Alzheimer's disease (AD) is the most widespread neurodegenerative disorder and has caused a major global health concern with the aging population. Early diagnosis of AD before irreversible brain damage or mental decline is critical for timely intervention, symptomatic treatment, and improved patient function. Accumulating studies indicate that neuron-derived extracellular vesicles (EVs) are important biomarkers for AD. However, researchers face significant challenges in the efficient isolation and accurate analysis of EVs, limiting the broad study and application of EVs in early diagnosis or targeted therapy of AD. WellSIM proposes to develop and validate a high-throughput platform and workflow based on our revolutionary EXODUS technique for reliable and reproducible isolation and analysis of EVs from plasma and CSF with unparalleled throughput, purity, yield, and sensitivity. Based on hi-EXODUS-NGS and hi-EXODUS-MS integrative analysis, transcriptomic and proteomic profiling of EVs will be developed to discover and detect EV-derived multi-class biomarkers for AD diagnosis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	WELLSIM BIOMEDICAL TECHNOLOGIES INC	160 E TASMAN DR	SAN JOSE	CA	95134	SANTA CLARA	USA	Aging Research	000	1	3/4/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $110,405 )
2022	2022	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Aging Research	002	1	9/16/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Aging Research	000	1	8/29/2022	SUPPLEMENT FOR EXPANSION	$110,405
2022	2021	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Aging Research	001	1	9/15/2022	NEW	$0
														Subtotal = $110,405

Issue Date FY: 2021 ( Subtotal = $251,359 )
2021	2021	WELLSIM BIOMEDICAL TECHNOLOGIES, INC.	930 CORAL RIDGE CIR	RODEO	CA	94572	CONTRA COSTA	USA	Aging Research	000	1	9/21/2021	NEW	$251,359
														Subtotal = $251,359

Grand Total All Awards = $361,764

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EXODUS-enabled High-throughput Multi-omics Profiling of Extracellular Vesicles for Diagnosis of Preclinical Alzheimer's Disease

Award Number: R41AG076098

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2021

PERIOD OF PERFORMANCE END DATE: 09/29/2023

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