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Precision mapping of individualized executive networks in youth

Award Number: R37MH125829
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Precision mapping of individualized executive networks in youth - ABSTRACT Executive function (EF) improves dramatically during childhood and adolescence, and failures of EF are associated with both a broad range of negative outcomes and diverse mental illnesses. The brain circuits responsible for EF are spatially distributed, and include the fronto-parietal, cingulo-opercular, and salience systems. These networks have typically been studied using standardized network atlases, which assume a straightforward mapping between structural and functional neuroanatomy across individuals. However, multiple independent efforts in adults using precision functional mapping techniques have recently demonstrated that there is marked inter-individual variation in functional topography, which is defined as the spatial distribution of functional networks on the cortex. The over-arching hypothesis of this proposal is that individual variation in functional topography is a critical determinant of EF in youth. Our collaborative team recently published the first report of individualized functional networks in children using a cross-sectional sample (Cui et al., Neuron 2020). In this proposal, we will build upon this initial work by replicating and generalizing this finding using two large cross-sectional datasets with high-resolution imaging: the Healthy Brain Network (HBN; n=5,000) and Human Connectome Project: Development (HCP-D, n=1,300). Critically, we will also leverage the unprecedented resources of the Adolescent Brain and Cognitive Development Study (ABCD, n=11,572) to delineate within-subject change in personalized networks. In this proposal, we will first harmonize these massive data resources using advanced techniques originally developed for statistical genomics (Aim 1). Next, we will describe how personalized networks evolve with age (Aim 2) and predict EF (Aim 3). Finally, we will use machine learning tools to discover how the functional topography of personalized executive networks predict dimensions of psychopathology in a data-driven manner (Exploratory Aim 4). Throughout, we will adhere to best practices of open science to maximize reproducibility, and ensure that all processed data, code, and results are openly shared with the neuroscience community. Together, this research will establish that functional topography is essential for understanding EF, and will motivate trials of personalized neuromodulatory therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $642,495 )
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Mental Health Research Grants	000	5	4/25/2025	NON-COMPETING CONTINUATION	$642,495
														Subtotal = $642,495

Issue Date FY: 2024 ( Subtotal = $765,247 )
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Mental Health Research Grants	000	4	4/29/2024	NON-COMPETING CONTINUATION	$765,247
														Subtotal = $765,247

Issue Date FY: 2023 ( Subtotal = $696,479 )
2023	2023	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Mental Health Research Grants	000	3	6/2/2023	NON-COMPETING CONTINUATION	$696,479
														Subtotal = $696,479

Issue Date FY: 2022 ( Subtotal = $743,290 )
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Mental Health Research Grants	000	2	4/19/2022	NON-COMPETING CONTINUATION	$743,290
														Subtotal = $743,290

Issue Date FY: 2021 ( Subtotal = $818,531 )
2021	2021	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Mental Health Research Grants	000	1	7/1/2021	NEW	$818,531
														Subtotal = $818,531

Grand Total All Awards = $3,666,042

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Precision mapping of individualized executive networks in youth

Award Number: R37MH125829

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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